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potassium iodide (Rx, OTC)Brand and Other Names:Pima Syrup, SSKI, more...iosat, ThyroSafe, ThyroShield

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 65mg
  • 130mg

oral solution

  • 65mg/mL
  • 325mg/5mL

oral solution (concentrated)

  • 1g/mL
more...

Radiation Emergency

Indicted during environmental radiation emergency to block uptake of radioactive iodine isotopes in thyroid and reduce risk of thyroid cancer

130 mg PO qDay; not to exceed 1 dose/24 hr

Ideally initiate 1-48 hr prior to exposure

Continue daily dose until exposure risk has passed and/or until other measures (eg, evacuation, sheltering, control of the food and milk supply) have been successfully implemented

Risk reduction with acute exposure

  • KI initiated shortly before or immediately after acute exposure: 90-99% risk reduction
  • KI initiated within 3-4 hr after acute exposure: 50% risk reduction
  • KI initiated up to 12 hr after acute exposure: limited benefit may be achieved

Expectorant

SSKI: 300-600 mg PO q6-8hr

Thyrotoxic Crisis

250-500 mg (5-10 gtt of 1 g/mL) PO q4-6hr

Preoperative Thyroidectomy

50-250 mg (1-5 gtt of 1 g/mL) PO q8hr for 10-14 days

Other Indications & Uses

Cystic fibrosis, chronic sinusitis (adjunct)

Dosage Forms & Strengths

tablet

  • 65mg
  • 130mg

oral solution

  • 65mg/mL
  • 325mg/5mL

oral solution

  • 1g/mL
more...

Radiation Emergency

Indicted during environmental radiation emergency to block uptake of radioactive iodine isotopes in thyroid and reduce risk of thyroid cancer

Infants <1 month: 16.25 mg PO qDay; not to exceed 1 dose/24 hr

1 month-3 years: 32.5 mg PO qDay; not to exceed 1 dose/24 hr

3-13 years: 65 mg PO qDay; not to exceed 1 dose/24 hr

>13 years or adolescents weighing >70 kg (154 lb): 130 mg PO qDay; not to exceed 1 dose/24 hr

Ideally initiate 1-48 hr prior to exposure

Continue daily dose until exposure risk has passed and/or until other measures (eg, evacuation, sheltering, control of the food and milk supply) have been successfully implemented

Risk reduction with acute exposure

  • KI initiated shortly before or immediately after acute exposure: 90-99% risk reduction
  • KI initiated within 3-4 hr after acute exposure: 50% risk reduction
  • KI initiated up to 12 hr after acute exposure: limited benefit may be achieved

Neonatal Graves Disease

SSKI: 1 gtt PO q8hr

Expectorant

SSKI: 60-250 mg PO q6hr

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Interactions

Interaction Checker

potassium iodide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Arrhythmia

            Skin rash

            Gastrointestinal irritation or bleeding

            Diarrhea

            Paresthesia

            Swelling or neck or throat

            Goiter

            Hypothyroidism

            Hyperthyroidism

            Myxedema

            Thyroid adenoma

            Allergic reactions (fever, rash)

            Lymph node swelling

            Salivary gland swelling/tenderness

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            Warnings

            Contraindications

            Iodine sensitivity (although allergy to radiocontrast media, contact dermatitis from iodine-containing antibacterials, allergy to seafood should NOT be considered evidence of potassium iodide allergy)

            Hyperthyroidism

            Respiratory failure

            Cautions

            Avoid repeat dosing in neonates or women who are pregnant or breastfeeding if possible; in acute radiation exposure, prioritize these individuals for evacuation; although these precautions should be taken, the benefits of short-term use of KI to block uptake of radioactive iodine by the thyroid gland far exceed its chances of side effects

            Prescribe for radiation exposure only upon order from authorities

            Caution in tuberculosis

            Iodine poisoining (Iodism): Metallic taste, sore mouth, severe headache

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            Pregnancy & Lactation

            Pregnancy Category: D

            Increased risk of thyroid suppression in the fetus and neonate leads to a specific recommendation that newborns and pregnant women be given priority with regard to evacuation, safe shelter, and safe food/milk during radiation emergency in order to obviate, as possible, the need for repeat dosing with KI

            Lactation: Excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Expectorant: Iodine helps to increase respiratory secretions and decrease viscosity

            Hyperthyroidism: Suppresses thyroid hormone synthesis

            Thyroid protective: Systemically circulating potassium iodide is readily taken up by thyroid gland by sodium/iodide transporter in basal membrane; concentration gradient of thyroid gland to plasma is 20-50:1

            Pharmacokinetics

            Distribution: Significant extracellular distribution, with most accumulation in thyroid gland

            Onset: Therapeutic effects in hyperthyroidism observed within 24 hr

            Maximum effect: After 10-15 days of therapy

            Duration of effect: Therapeutic effect may persist up to 6 weeks after chronic administration; 24 hr for radioactive iodine exposure

            Metabolism: Unknown

            Excretion: Renal

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            Formulary

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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