plasma protein fraction (Rx)

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Brand and Other Names:Plasma Plex, Plasmanate, more...Plasmatein, Protenate

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable solution

  • 5%
more...

Treatment of Shock

250-500 mL (12.5-25 g of protein) IV PRN based on response

Monitor for signs of hypervolemia

Hypovolemia

250-500 mL (12.5-25 g of protein) IV PRN based on response

Dosage Forms & Strengths

injectable solution

  • 5%
more...

Treatment of Shock

Safety & efficacy not established; useful in infants & small children for initial treatment of shock resulting from dehydration & infection

6.6-33 mL/kg (0.33-1.65 g/kg of protein) IV infusion at 5-10 mL/min PRN 

Monitor: signs of hypervolemia

Treatment of shock

250-500 mL (12.5-25 g of protein) IV PRN based on response

Monitor for signs of hypervolemia

Hypovolemia

250-500 mL (12.5-25 g of protein) IV PRN based on response

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Adverse Effects

Frequency Not Defined

Hypotension

Anaphylaxis

Dyspnea

Pulm. edema

Flushing

Tachycardia

Erythema

Urticaria

N/V

Chills

Fever

Headache

Back pain

Hypersalivation

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Warnings

Contraindications

Hypersensitivity to albumin, severe anemia, CHF, increases intravascular volume

Hypoproteinemia associated with chronic nephrosis, chronic cirrhosis, malabsorption, protein-losing enteropathies, pancreatic insufficiency, and malnutrition

Patients undergoing cardiopulmonary bypass

Cautions

Allergy to corn, liver disease, renal impairment

Risk of pulmonary edema or CHF

Ineffective in chronic cases of nephrosis, cirrhosis, malabsorption, enteropathies

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known if distributed into breast milk, avoid

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Replacement of plasma protein

Pharmacokinetics

Half-Life: 15-20 d

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Administration

IV Compatibilities

Whole blood, packed red blood cells, standard carbohydrate & electrolyte solutions

IV Incompatibilities

Protein hydrolysates, solutions containing alcohol, norepinephrine

IV Administration

Infuse at rate PRN NMT 5-8 mL/min

Peds: IV infuse at 5-10 mL/min

Storage

Store at room temperature (NMT 30°C)

Do not freeze

Do not use if protein colloid appears turbid, vial is damaged or if 4 hr passed since container was first entered

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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