ephedrine (pulmonary) (Discontinued)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Please refer to ephedrine monograph

Please refer to ephedrine monograph

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Interactions

Interaction Checker

and ephedrine (pulmonary)

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Anxiety

            Insomnia

            Nervousness

            Palpitations

            Tachycardia

            Vertigo

            Difficult and painful urination (vesical sphincter spasm)

            Precordial pain and cardiac arrhythmias may occur from ephedrine sulfate injection

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            Warnings

            Contraindications

            Hypersensitivity to ephedrine or other sympathomimetic agents

            Angle-closure glaucoma

            Concurrent use of other sympathomimetic agents

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Likely excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Alpha, beta-1, & beta-2 receptor agonist

            Pharmacokinetics

            Onset: 10-20 min (SC/IM);15-60 min (PO)

            Half-Life: 4.85-6.47

            Duration: <1 hr (SC/IM); 3-5hr (PO)

            Peak Plasma: PO: 20-80 ng/mL

            Vd: 220-240 L

            Metabolism: liver

            Metabolites: p-hydroxyephedrine, p-hydroxynorephedrine, norephedrine, and their conjugates

            Clearance: 25.5-34.1 L/hr

            Excretion: urine

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