propantheline (Rx)

Brand and Other Names:Pro Banthine
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 15mg
more...

Peptic Ulcer

15 mg PO q8hr AC & 30 mg PO qHS

Use 7.5 mg PO q8hr for mild conditions

Administration: take 30-60 min before a meal

Antispasmodic

15 mg PO q8hr AC & 30 mg PO qHS

Other Indications & Uses

PUD (adjunctive treatment)

Off-label: Other conditions requiring antispasmodic and antisecretory agents, neurogenic bladder

Dosage Forms & Strengths

tablet

  • 15mg
more...

Antisecretory

1-2 mg/kg/day PO q6-8hr 

Antispasmodic

2-3 mg/kg/day PO divided q4-6hr & qHS 

Peptic Ulcer

Safety & efficacy not established

Administration

Take 30-60 min before a meal

Avoid except in short-term situations to decrease secretions; high incidence of anticholinergic effects (Beers Criteria)

Peptic Ulcer

Administer 7.5 mg PO q8hr AC and qHS; not to exceed 30 mg q8hr

Antispasmodic

15 mg PO q8hr AC & 30 mg PO qHS

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Interactions

Interaction Checker

and propantheline

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Constipation

            Dry mouth

            Dry skin

            Decreased sweating

            Frequency Not Defined

            Blurred vision

            Sedation

            Tachycardia

            Dysphagia

            Urinary retention

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            Warnings

            Contraindications

            Hypersensitivity to propantheline or related compounds

            Closed-angle glaucoma, myasthenia gravis, hemorrhage w/ cardiovascular instability, paralytic ileus, intestinal atony of elderly/debilitated pt, obstructive uropathy, toxic megacolon, GI obstruction, tachycardia secondary to cardiac insufficiency or thyrotoxicosis

            Cautions

            Renal/hepatic/ impairment, BPH, CHF, CAD, HTN, COPD, hiatal hernia, reflux esophagitis, mitral stenosis, brain damage or spastic paralysis in children, salivary secretion d/o, Down synd, autonomic neuropathy, hyperthyroidism, tachyarrythmia, toxin-mediated diarrhea

            Elderly (see Beers Criteria)

            Risk of heat prostration in high environmental temperature

            May affect alertness/ability to perform hazardous tasks

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known whether excreted into breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Competitively blocks the action of ACh at postganglionic parasympathetic muscarinic receptor sites

            Absorption

            Bioavailability: PO <50%, take 30 min before meals

            Onset: 30-45 min (PO)

            Duration: Upt to 6 hr (PO)

            Metabolism

            Liver and GI tract

            Elimination

            Half-life elimination: Biphasic: 57.9 min and 2.93 hr

            Total Body Clearance: 79.2 L/hr

            Renal Clearance: 11.5 L/hr

            Excretion: Urine 6-17.3%, bile, and other body fluid

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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