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probenecid (Rx)Brand and Other Names:Benemid

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 500mg
more...

Gout

250 mg PO twice daily for 1 week; increase to 500 mg PO twice daily to 2 g/day maximum with dosage increases of 500 mg q4weeks

If gout attacks do not occur for 4 months and uric acid levels are within normal may reduce dose by 500 mg q6monts

Prolong Penicillin Serum Levels

500 mg PO four times daily

Pelvic Inflammatory Disease

1 g PO with 2 g cefoxitin IM as single dose

Gonorrhea

1 g PO with 2 g cefoxitin IM as single dose

Renal Impairment

CrCl<30 mL/min: Avoid use

Dosage Forms & Strengths

tablet

  • 500mg
more...

Prolong Penicillin Serum Levels

<2 years old

  • Contraindicated

>2 years old

  • <45 kg: Load 25 mg/kg PO once with PCN; increase to 40 mg/kg/day PO divided q6hr; not to exceed 500 mg/dose 
  • >45 kg: 500 mg PO four times daily

Gonorrhea

<50 kg

  • Safety and efficacy not established

>50 kg

  • 1 g PO with 2 g cefoxitin IM as single dose
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Interactions

Interaction Checker

probenecid and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
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            Adverse Effects

            1-10%

            Headache

            Nausea

            Vomiting

            Loss of appetite

            GI upset

            Rash

            Flushing

            Dizziness

            Fever

            Aplastic anemia

            Hemolytic anemia

            Leukopenia

            Renal calculi

            Nephrotic syndrome (rare)

            Exacerbation of gout

            Gouty arthritis

            Hepatic necrosis (rare)

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            Warnings

            Contraindications

            <2 years

            Uric acid kidney stones, acute gouty arthritis

            Hypersensitivity

            Blood dyscrasias

            Small or large dose aspirin therapy

            Cautions

            PUD, renal impairment (CrCl <50 mLmin)

            Do NOT administer for acute gouty attacks; if acute precipitation occurs during treatment may continue therapy

            Alkalinize urine to avoid renal calculi

            Use caution in patients with G6PD deficiency; may increase risk for hemolytic anemia

            Discontinue if allergic reaction occurs

            Use caution in patients with peptic ulcer disease

            May cause exacerbation of acute gouty attack

            Monotherapy may not be effective in patients with a creatinine clearance <30 mL/min

            May increase serum concentration of methetrexate (avoid concomitant administration)

            Use of probenecid with penicillin in patients with with renal insufficiency is not recommended

            Salicylates may reduce the therapeutic effects of probenecid (effect may be pronounced with high chronic doses

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: Not known if distributed into breast milk, use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            (Uricosuric) inhibits tubular reabsorption of urate; increasing uric acid excretion

            Also inhibits tubular secretion of weak organic acids like PCNs & cephalosporins

            Pharmacokinetics

            Half-Life: 3-17 hr

            Onset: 2 hr (effect on penicillin levels)

            Peak Plasma Time: 2-4 hr

            Bioavailability: >90%

            Protein Bound: 85-95% (albumin)

            Metabolism: Liver

            Metabolites: hydroxylated metabolites, N-despropyl metabolite, probenecid acylglucuronide

            Excretion: Urine

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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