Progesterone, Natural (OTC)

Brand and Other Names:
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Suggested Dosing

20 mg (1/4 tsp) cream/day applied topically to thighs or upper arms, for 20 days out of each month

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Suggested Uses

Vasomotor symptoms of menopause, osteoporosis, PMS

Efficacy

Positive studies for menopausal vasomotor symptoms

Results mixed or negative for osteoporosis, PMS

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Interactions

Interaction Checker

and Progesterone, Natural

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Vaginal spotting

            Rash

            Edema

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            Warnings

            Contraindications

            Pregnancy, hypersensitivity

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Diosgenin from Mexican yams (Dioscorea spp.) chemically altered to be identical to human progesterone

            Unaltered "yam extract" has little or no progesterone activity

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