20 mg (1/4 tsp) cream/day applied topically to thighs or upper arms, for 20 days out of each month
Vasomotor symptoms of menopause, osteoporosis, PMS
Positive studies for menopausal vasomotor symptoms
Results mixed or negative for osteoporosis, PMS
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Pregnancy & Lactation
Pregnancy Category: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Diosgenin from Mexican yams (Dioscorea spp.) chemically altered to be identical to human progesterone
Unaltered "yam extract" has little or no progesterone activity