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estazolam (Rx)Brand and Other Names:ProSom

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet: Schedule IV

  • 1mg
  • 2mg
more...

Insomnia

1-2 mg PO qHS

Hepatic Impairment

Use caution; dose adjustment may be necessary

Safety & efficacy not established

Initial dose: 0.5 mg PO qDay in small elderly patients; healthy patients may receive 1 mg

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Interactions

Interaction Checker

estazolam and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Somnolence (42%)

            Headache (16%)

            Asthenia (11%)

            Neuromuscular & skeletal weakness

            1-10%

            Dizziness (7-8%)

            Hypokinesia (7-8%)

            Abnormal coordination (4%)

            Hangover (3%)

            Abnormal thinking (2%)

            Flushing palpitation

            Hangover effect

            Euphoria

            Hostility

            Seizure

            Sleep disorder

            Rash

            Urticaria

            <1%

            Angioedema

            Sleep-driving (sleep-cooking, sleep eating, etc) may occur

            Muscle spasm

            Fever

            Neck pain

            Myalgia

            Drug dependence may occur

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            Warnings

            Contraindications

            Documented hypersensitivity

            Acute alcohol intoxication

            Myasthenia gravis (allowable in limited circumstances)

            Narrow angle glaucoma (questionable)

            Severe respiratory depression

            Depressed neuroses, psychotic reactions

            IV use in shock, coma, depressed respiration, patients who recently received other respiratory depressants

            Cautions

            Use caution in respiratory diseases, sleep apnea, renal/hepatic disease, open-angle glaucoma (questionable), impaired gag reflex, clinical depression, suicide ideation, patients receiving other CNS depressants concurrently

            Use caution in patients with history of drug abuse or acute alcoholism; tolerance, psychological and physical dependence may occur with prolonged use

            Anterograde amnesia

            May cause CNS depression that impairs mental and physical abilities

            Hyperactive or aggressive behavior may occur

            May impair ability to perform hazardous tasks

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: Enters breast milk/contraindicated

            Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations

            Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence)

            Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Depresses all levels of CNS (eg, limbic and reticular formation), possibly by increasing membrane permeability to chloride ions, which in turn increases the inhibitory activity of GABA on neuronal excitability.

            Pharmacokinetics

            Half-Life: 10-24 hr

            Duration: Variable

            Peak Plasma Time: 0.5-1.6 hr

            Protein Bound: 93%

            Metabolism: Hepatic

            Metabolites: Inactive

            Excretion: Urine

            Half-life elimination: 10-24 h, and peak action is 2 h

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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