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modafinil (Rx)Brand and Other Names:Provigil

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet: Schedule IV

  • 100mg
  • 200mg
more...

Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

200 mg PO qAM; no more than 400 mg

Narcolepsy

200 mg PO qAM; no more than 400 mg

Shift Work Sleep Disorder

200 mg PO 1 hour prior to patient's work shift

Other Indications & Uses

Off-label: Reduce fatigue in MS patients, depression

Dosing Modifications

Hepatic impairment, severe: 100 mg PO qAM

Dosage Forms & Strengths

tablet: Schedule IV

  • 100mg
  • 200mg
more...

Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

<16 years

  • Not recommended

>16 years

  • 200 mg PO qAM; no more than 400 mg

Narcolepsy

<16 years

  • Not recommended

>16 years

  • 200 mg PO qAM; no more than 400 mg

Shift Work Sleep Disorder

<16 years

  • Not recommended

>16 years

  • 200 mg PO 1 hour prior to patient's work shift
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Interactions

Interaction Checker

modafinil and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
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            Adverse Effects

            >10%

            Headache (45-50%)

            Rhinitis (11-15%)

            Decreased appetite (16%)

            Nausea (11%)

            Abdominal pain (12%)

            1-10%

            Nervousness (6-10%)

            Syncope (1-5%)

            Frequency Not Defined

            Arrhythmia

            Hypotension

            Hypertension

            T-wave changes

            Amnesia

            Anxiety

            Cataplexy

            Chills

            Depression

            Dizziness

            Epistaxis

            Fever

            Insomnia

            Paresthesia

            Reversible psychosis (rare)

            Tremor

            Drug hypersensitivity syndrome

            Stevens-Johnson syndrome

            Toxic epidermal necrolysis due to drug

            Anorexia

            Diarrhea

            Dry mouth

            Mouth ulcer

            Vomiting

            Abnormal LFT

            Chest pain

            Neck pain

            Dyspnea

            Pharyngitis

            Postmarketing Reports

            Aggression

            Psychomotor hyperactivity

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Risk of skin reactions (eg SJS, toxic necrolysis, and drug rash with eosinophilia and systemic symptoms); discontinue if rash or other hypersensitivity reactions occur

            May impair ability to operate heavy machinery and perform hazardous tasks

            Not recommended in patients with angina, cardiac ischemia, recent history of myocardial infarction, left ventricular hypertrophy, or mitral valve prolapse

            Use with caution in severe hepatic impairment, elderly, history of: depression, psychosis (may exacerbate psychiatric symptoms), or mania

            Consider dose adjustment of CYP3A4/5 substrate medications

            Use with caution in patients with Tourette's syndrome; stimulants may unmask ticks

            May reduce effectiveness of steroidal contraceptives 1 month after discontinuation of drug therapy

            Reassess degree of sleepiness frequently; if used adjunctively with continuous positive airway pressure (CPAP): Periodic assessment of CPAP compliance is necessary

            Discontinue at first sign of serious rash

            Discontinue therapy if symptoms suggest angioedema or anaphylaxis

            Discontinue if multiorgan hypersensitivity reaction is suspected

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Unknown; not sympathomimetic; may increase dopamine levels in the brain by binding to the dopamine transporter and inhibiting dopamine reuptake

            Absorption

            Peak plasma time: 2-4 hr

            Distribution

            Protein bound: 60%

            Vd: 0.9 L/kg

            Metabolism

            Hepatic

            Enzymes induced: CYP1A2, CYP2B6, CYP3A4; induces its own metabolism (chronic)

            Enzymes inhibited: CYP2C19

            Elimination

            Half-life: 15 hr

            Excretion: Urine (80%)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
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            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

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