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doxepin cream (Rx)Brand and Other Names:Prudoxin, Xepin, more...Zonalon

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream

  • 5%
more...

Pruritus

Apply to affected area QID

Administration

Allow at least 3-4 hour intervals

No more than 8 days chronic use

Other Indications & Uses

Associated with atopic dermatitis, lichen simplex chronicus

Not recommended

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Interactions

Interaction Checker

doxepin cream and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Burning/stinging (23%)

            Drowsiness (20%; esp if applied to >10% BSA)

            1-10%

            Dizziness

            Dry mouth

            Eczema exacerbated

            Edema

            Fatigue

            Mental changes

            Pruritus

            Taste perversion

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            Warnings

            Contraindications

            Hypersensitivity

            Narrow-angle glaucoma

            Urinary retention

            Side effects incr by MAO inhibitors; discontinue MAOIs 2 wk before doxepin

            Cautions

            Risk of drowsiness

            Possibility of significant systemic absorption, resulting in anticholinergic effects

            Allow at least 3-4 hr between applications

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: may pass into breast milk; do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Absorption: may be significant

            Metabolism: CYP2D6

            Mechanism of Action

            Potent histamine H1- & H2-receptor antagonist activity

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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