Brand and Other Names:Prudoxin, Xepin, more...Zonalon
- Classes: Topical Skin Products
Dosing & Uses
Dosage Forms & Strengths
Apply to affected area QID
Allow at least 3-4 hour intervals
No more than 8 days chronic use
Other Indications & Uses
Associated with atopic dermatitis, lichen simplex chronicus
Serious - Use Alternative
Significant - Monitor Closely
Drowsiness (20%; esp if applied to >10% BSA)
Side effects incr by MAO inhibitors; discontinue MAOIs 2 wk before doxepin
Risk of drowsiness
Possibility of significant systemic absorption, resulting in anticholinergic effects
Allow at least 3-4 hr between applications
Pregnancy & Lactation
Pregnancy Category: B
Lactation: may pass into breast milk; do not nurse
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Absorption: may be significant
Mechanism of Action
Potent histamine H1- & H2-receptor antagonist activity
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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