Brand and Other Names:Quadramet
- Classes: Radiopharmaceuticals
Dosing & Uses
Dosage Forms & Strengths
< 16 years old: Safety & efficacy not established
Hgb decr (40.7%)
Spinal cord compression
Pain flare rxn
CHF, renal impairment, bone marrow depression
Does not prevent spinal cord compression
Pts at risk for hypocalcemia
Pt's urine will be radioactive for several hr, take appropriate precautions
Pregnancy & Lactation
Pregnancy Category: D
Lactation: discontinue drug or do not nurse
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Excretion: urine 20-50%
Mechanism of Action
Tetraphosphonate chelating agent that concentrates in bone - precise mechanism unknown
Over 1 min through in-dwelling catheter
Do not dilute or mix with other solutions
Contains calcium - may form calcium precipitates with chemicals that complex with calcium
Store frozen at -10°C to -20°C in lead-shielded container
Expires 48 hr after time of calibration (noted on label) or 8 hr after thawing, whichever is earlier
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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