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samarium sm 153 lexidronam (Rx)Brand and Other Names:Quadramet

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 50mCi/mL
more...

Metastatic Bone Pain Relief

1 mCi/kg IV 

Through secure in-dwelling catheter over 1 minute, followed with saline flush

Patient should ingest (or given by IV) 500 mL fluid & void as often as possible to minimize bladder radiation exposure

< 16 years old: Safety & efficacy not established

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Adverse Effects

>10%

Thrombocytopenia (69.3%)

Leukopenia (59.3%)

Hgb decr (40.7%)

Nausea/vomiting (32.7%)

1-10% (undefined)

Arrhythmias

CVA

Ecchymosis

Epistaxis

HTN

Hypotension

Dizziness

Fever

Paresthesia

Pathologic fx

Spinal cord compression

Purpura

Rash

Abdominal pain

Diarrhea

Coagulation d/o

Hematuria

Bronchitis

Chest pain

Pneumonia

Infections

Lymphadenopathy

Oral candidiasis

Pain flare rxn

Myasthenia

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Warnings

Contraindications

Hypersensitivity

Cautions

CHF, renal impairment, bone marrow depression

Avoid pregnancy

Causes myelosuppression

Does not prevent spinal cord compression

Pts at risk for hypocalcemia

Pt's urine will be radioactive for several hr, take appropriate precautions

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Pregnancy & Lactation

Pregnancy Category: D

Lactation: discontinue drug or do not nurse

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Metabolism: none

Excretion: urine 20-50%

Mechanism of Action

Tetraphosphonate chelating agent that concentrates in bone - precise mechanism unknown

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Administration

IV Administration

Over 1 min through in-dwelling catheter

Do not dilute or mix with other solutions

Contains calcium - may form calcium precipitates with chemicals that complex with calcium

Storage

Store frozen at -10°C to -20°C in lead-shielded container

Expires 48 hr after time of calibration (noted on label) or 8 hr after thawing, whichever is earlier

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Images

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Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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