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beclomethasone, inhaled (Rx)Brand and Other Names:Qvar

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

MDI

  • 40mcg/actuation
  • 80mcg/actuation
more...

Chronic Asthma

No prior history of inhaled corticosteroid use: 40-80 mcg inhaled PO BID; do not exceed 320 mcg BID

Prior history of inhaled corticosteroid use: 40-160 mcg inhaled PO BID; do not exceed 320 mcg BID

Administration

Prime inhaler (2 actuations into air) before first use and after prolonged idleness (>10 days)

Dosage Forms & Strengths

MDI

  • 40mcg/inhaler
  • 80mcg/inhaler
more...

Chronic Asthma

<5 years: Safety and efficacy not established

5-12 years: 40 mcg inhaled PO BID for patients with/without prior history of inhaled corticosteroid use; do not exceed 80 mcg inhaled BID

>12 years

  • No prior history of inhaled corticosteroid use: 40-80 mcg inhaled PO BID; do not exceed 320 mcg BID
  • Prior history of inhaled corticosteroid use: 40-160 mcg inhaled PO BID; do not exceed 320 mcg BID

Dosing Considerations

May cause growth velocity reduction with extended use; monitor closely if on prolonged therapy

Administration

<5 years: Use with spacer device is not recommended

Start at lower end of dosing range due to increased risk of adverse effects

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Interactions

Interaction Checker

beclomethasone, inhaled and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Pharyngitis (5-27%)

            Headache (8-25%)

            URI (5-11%)

            1-10%

            Rhinitis (3-7%)

            Pain (1-5%)

            Increased asthma symptoms (2-4%)

            Dysphonia (1-4%)

            Sinusitis (3%)

            Oral symptoms (2-3%)

            Nausea (1-2%)

            Postmarketing Reports

            Psychiatric events and behavioral changes (eg, aggression, depression, sleep disorders, psychomotor hyperactivity, and suicidal ideation [primarily in children])

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            Warnings

            Contraindications

            Hypersensitivity

            Primary treatment of status asthmaticus, acute bronchospasm

            Cautions

            Respiratory tract TB

            Untreated fungal or bacterial infections

            Viral/parasitic infections

            Ocular herpes simplex

            Nasal septum perforation

            Wheezing

            Cataracts

            Glaucoma

            Increased IOP

            Risk for more serious or fatal course of chickenpox or measles in susceptible patients (eg, unvaccinated or immunologically unexposed individuals); care must be taken to avoid exposure

            Deaths have occurred due to adrenal insufficiency following abrupt withdrawal of oral steroids; taper withdrawal gradually

            May decrease growth velocity in children

            Immunocompromised patients

            Risk of infections of nose and pharynx, including Candida albicans; must rinse mouth after inhalation to reduce risk

            Risk of bronchospasm with immediate increase in wheezing after administration; if this occurs, discontinue therapy and administer SABA immediately

            Excessive use may suppress HPA function; monitor closely, especially postoperatively or during periods of stress

            During periods of stress or severe status asthmaticus, may require supplementary systemic corticosteroids immediately; patient should carry warning card indicating possible need for supplementary systemic steroids in such emergencies

            Switching from systemic steroids to therapy may unmask allergic conditions (eg, conjunctivitis, eczema, rhinitis)

            Prolonged corticosteroid use may result in elevated IOP, glaucoma, and/or cataracts

            Not a bronchodilator; should not be administered for rapid relief of acute bronchospasm

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Potential for excretion into milk; use only if benefits greatly outweigh risks

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Potent anti-inflammatory glucocorticoid; inhibits inflammatory cells and release of inflammatory mediators

            Absorption

            Bioavailability: 20% systemic

            Onset: 1-3 weeks

            Duration: 6 hr

            Peak plasma concentration: 88 pg/mL

            Distribution

            Protein binding: 94-96% over concentration range of 1000-5000 pg/mL

            Metabolism

            Prodrug; rapidly activated by hydrolysis to active monoester (17-BMP)

            Liver (CYP450-3A)

            Elimination

            Half-life: 30 minutes (17-BMP: 2.8 hr)

            Excretion: Feces (major), urine (<10%)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Select a class to view formulary status for similar drugs

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