Prussian blue (Rx)

Brand and Other Names:Radiogardase, ferric hexacyanoferrate
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 500mg
more...

Cesium or Thallium Contamination

Indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or nonradioactive thallium to increase their rates of elimination

3 g PO q8hr; 30 day treatment minimum

Administration

Initiate as soon as contaminated is suspected or as soon as drug becomes available; monitor radioactivity levels before, during and after treatment to determine treatment duration

Dosage Forms & Strengths

capsule

  • 500mg
more...

Cesium or Thallium Contamination

Indicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or nonradioactive thallium to increase their rates of elimination

<2 years: Safety and efficacy not established

2-12 years: 1 g PO q8hr; minimum 30 days treatment

>12 years: As adult; 3 g PO q8hr; 30 day treatment minimum

Administration

Initiate as soon as contaminated is suspected or as soon as drug becomes available; monitor radioactivity levels before, during and after treatment to determine treatment duration

Patients unable to swallow may be given capsules opened and mixed with bland food or liquids; may cause blue discoloration of mouth and teeth

Renal Impairment

Not studied

Hepatic Impairment

Effectiveness may decrease due to failure to excrete cesium and thallium

Next:

Adverse Effects

>10%

Constipation (24%)

1-10%

Asymptomatic hypokalemia (7%)

Previous
Next:

Warnings

Contraindications

None

Cautions

Monitor for decreased gastrointestinal motility if radiation absorbed dose to gastrointestinal mucosa increased

Monitor and treat constipation

Monitor for serum electrolyte abnormalities during treatment

Blue discoloration of stool, oral mucosa, and dentition may occur

Previous
Next:

Pregnancy & Lactation

Pregnancy Category: C (risk of toxicity from untreated radioactivity likely higher than risk from Radiogardase)

Lactation: unknown; unlikely to be excreted in breast milk (women internally contaminated with radioactivity should not breastfeed anyway)

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
Previous
Next:

Pharmacology

Mechanism of Action

Reduces gastrointestinal reabsorption by binding to cesium & thallium isotopes in the GI tract after ingestion or excretion in bile

Pharmacokinetics

Bioavailability: Not systemically bioavailable

Excretion: Feces (99% unchanged)

Previous
Next:

Images

Previous
Next:

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Additional Offers
Email to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Email Forms to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Previous