modified ragweed tyrosine adsorbate (Discontinued)

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Brand and Other Names:ragweed vaccine

Dosing & Uses

AdultPediatric

Not available in United States

Dosage Forms & Strengths

injectable solution

  • 500
  • 1400
  • 4300
  • 210 units/mL (set of four 0.5 mL syringes)
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Preseasonal Immunotherapy (Allergic Rhinitis due to Ragweed)

0.5 mL SC qWeek x 4 weeks

Use numbered syringes in order (1, 2, 3, 4)

Administer before ragweed season (start administration in late June)

Not available in United States

Dosage Forms & Strengths

injectable solution

  • 500
  • 1400
  • 4300
  • 210 unit/mL (set of four 0.5 mL syringes)
more...

Preseasonal Immunotherapy (Allergic Rhinitis due to Ragweed)

>8 years old: Same as adult

<8 years old: Not recommended

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Adverse Effects

Frequency Not Defined

Hypersensitivity S/S

Inj site reaction

Wheezing

Nasal congestion

Chest tightness

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Warnings

Contraindications

History of severe anaphylactic reaction to ragweed vaccine

Cautions

May pre-medicate w/ antihistamine 1 hr before inj

Be aware for signs of anaphylaxis; observe pt. in office for 20-30 min. after inj

Do not administer during ragweed season (mid-August to end of Sept.)

Wait 24 hr after fever or acute asthma attack before administration

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Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: not known if excreted in breast milk

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Extract of ragweed (Ambrosia elatior) pollen; increased IgG may interfere with immediate hypersensitivity reaction

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Images

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