Dosing & Uses
Dosage Forms & Strengths
Diabetic Neuropathic Ulcers
Amount to be applied will vary depending upon size of ulcer area
Formula in inches per tube size
- 15 g tube: Length of ulcer × width × 0.6 = Length of gel (inches)
- 2 g tube: Length of ulcer × width × 1.3 = Length of gel (inches)
Formula in centimeters per tube size
- 15 g tube: Length of ulcer × width ÷ 4 = Length of gel (cm)
- 2 g tube: Length of ulcer × width ÷ 2 = Length of gel (cm)
Squeeze calculated length of gel onto clean surface, then spread evenly over ulcer using cotton swab, tongue depressor or similar implement
Cover gel with saline-moistened dressing for 12 hours; then rinse off residual gel with saline & apply new saline-moistened dressing (no gel)
Re-measure ulcer weekly or bi-weekly to adjust dosage
If ulcer size not decreased 30% in 10 weeks, or not healed in 20 weeks, reassess continued treatment with becaplermin
<16 years old: Safety & efficacy not established
Tunneling of ulcer
Black Box Warnings
An increased risk of mortality secondary to malignancy was observed in patients treated with 3 or more tubes of becaplermin gel in a postmarketing retrospective cohort study. It should only be used when the benefits can be expected to outweigh the risks. This drug should be used with caution in patients with known malignancy.
Neoplasm at application site
Increased risk of cancers if exposed to 3 or more tubes
Do not use on self-healing wounds
Store in fridge; do NOT freeze
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Recombinant human PDGF-BB; stimulates chemotactic recruitment of wound-healing cells; promotes angiogenesis and induces fibroblast proliferation and differentiation to promote wound healing; granulation tissue enhancer
Onset of action: Within 8 weeks (15% completely healed); within 10 weeks (25% completely healed)
Distribution: Binds to normal skin and granulation tissue
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Select a box to add or remove a plan.
Select a class to view formulary status for similar drugs