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temazepam (Rx)Brand and Other Names:Restoril

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

capsule: Schedule IV

  • 7.5mg
  • 15mg
  • 22.5mg
  • 30mg
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Insomnia

15-30 mg PO qHS

Debilitated patients: 7.5 mg PO qHS

Dosing considerations

  • Discontinuation: Gradually taper after extended therapy; abrupt discontinuation should be avoided

Safety and efficacy not established

Preferred drug in elderly when benzodiazepine indicated because of lack of active metabolite

Insomnia

7.5 mg PO qHS; limit use to 10-14 days

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Interactions

Interaction Checker

temazepam and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Drowsiness (9.1%)

            Dizziness (4.5%)

            Lethargy (4.5%)

            Hangover (2.5%)

            Diarrhea (1.7%)

            Euphoria (1.5%)

            Weakness (1.4%)

            Confusion (1.3%)

            Vertigo (1.2%)

            < 1%

            Amnesia

            Angioedema

            Blood dyscrasias

            Sleep-related behavior (eg, sleep driving, sleep cooking, sleep eating)

            Ataxia

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            Warnings

            Contraindications

            Documented hypersensitivity

            Acute alcohol intoxication

            Narrow-angle glaucoma (questionable)

            Caution

            Use caution in COPD, sleep apnea, renal/hepatic disease, impaired gag reflex, open-angle glaucoma (questionable), alcoholism, respiratory disease, depression, suicidal ideation

            May impair ability to perform hazardous tasks

            Caution with IV use in shock, coma, and depressed respiration and in patients who recently received other respiratory depressants

            Anterograde amnesia may occur

            Use in myasthenia gravis is allowed in limited circumstances

            Use caution in severe respiratory depression and depressed neuroses, psychotic reactions

            Paradoxical hyperactive aggressive behavior reported

            May impair physical or mental abilities

            May cause hyperactive or aggressive behavior

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: Avoid if breastfeeding

            Minor tranquilizers should be avoided in 1st trimester of pregnancy due to increased risk of congenital malformations

            Maternal use shortly before delivery is associated with floppy infant syndrome (good and consistent evidence)

            Prenatal benzodiazepine exposure slightly increased oral cleft risk (limited or inconsistent evidence)

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Depresses all levels of CNS (eg, limbic and reticular formation), possibly by increasing membrane permeability to chloride ions, which in turn increases the inhibitory activity of GABA on neuronal excitability.

            Absorption

            Peak plasma time: 2-3 hr

            Peak plasma concentration: 260-210 ng/mL

            Distribution

            Protein bound: 96%

            Vd: 1.4 L/kg

            Metabolism

            Metabolized by CYP3A4 (minor), glucuronic acid conjugation

            Metabolites: Inactive

            Elimination

            Half-life elimination: 9.5-12.4 hr

            Excretion: Urine (80-90%)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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