tretinoin topical (Rx)

Brand and Other Names:Retin A, Renova, more...Atralin, Avita, Refissa, Retin-A Micro, Tretin-X
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical cream

  • 0.02% (Renova)
  • 0.025% (Retin-A, Avita, Tretin-X)
  • 0.0375% (Tretin-X)
  • 0.05% (Retin-A, Renova, Refissa, Tretin-X)
  • 0.075% (Tretin-X)
  • 0.1% (Retin-A, Tretin-X)

topical gel

  • 0.01% (Retin-A)
  • 0.025% (Retin-A, Avita)
  • 0.04% (Retin-A Micro)
  • 0.05% (Atralin)
  • 0.08% (Retin-A Micro)
  • 0.1% (Retin-A Micro)

topical solution

  • 0.05% (Retin-A)
more...

Acne Vulgaris

Retin-A, Atralin, Avita, Retin-A Micro, Tretin-X

  • Apply a pea-sized amount topically qHS to the skin where acne lesions appear, using enough to lightly cover the entire affected area
  • Begin therapy with a low-concentration formulation (0.025% cream, 0.04% microsphere gel, or 0.01% gel); may use stronger preparations as tolerated

Facial Wrinkles

Adjunct for mitigation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin

Renova, Refissa

  • Apply a pea-sized amount (0.02-0.05%) to the affected area qHS

Administration

Apply 20 minutes after skin is cleansed and completely dried

Avoid lips and directly under eyes

Avoid UV exposure

Dosage Forms & Strengths

topical cream

  • 0.02% (Renova)
  • 0.025% (Retin-A, Avita, Tretin-X)
  • 0.0375% (Tretin-X)
  • 0.05% (Retin-A, Renova, Refissa, Tretin-X)
  • 0.075% (Tretin-X)
  • 0.1% (Retin-A, Tretin-X)

topical gel

  • 0.01% (Retin-A)
  • 0.025% (Retin-A, Avita)
  • 0.04% (Retin-A Micro)
  • 0.05% (Atralin)
  • 0.08% (Retin-A Micro)
  • 0.1% (Retin-A Micro)

topical solution

  • 0.05% (Retin-A)
more...

Acne Vulgaris

Retin-A, Atralin, Avita, Retin-A Micro, and Tretin-X

  • <12 years old: Safety and efficacy not established
  • ≥12 years old: Apply a pea-sized amount topically qHS to the skin where acne lesions appear, using enough to lightly cover the entire affected area
  • Begin therapy with a low-concentration formulation (0.025% cream, 0.04% microsphere gel, or 0.01% gel); may use stronger preparations as tolerated

Administration

Apply 20 minutes after skin is cleansed and completely dried

Avoid lips and directly under eyes

Avoid UV exposure

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Interactions

Interaction Checker

and tretinoin topical

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Excessive dryness

            Erythema

            Scaling

            Pruritus

            Hyperpigmentation/hypopigmentation

            Photosensitivity

            Initial acne flare-up

            Edema

            Blistering

            Stinging

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            Warnings

            Contraindications

            Hypersensitivity

            Sunburn

            Cautions

            Extreme caution in eczema (may produce severe irritation of eczematous skin)

            Discontinue if sensitivity or chemical irritation occurs

            Exposure to UV light (including from sunlamps) increases intensity of inflammatory reaction

            Concomitant topical medications such as abrasive soaps, cleansers, or cosmetics with strong drying effects may increase skin irritation

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Not known whether excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits microcomedo formation; decreases cohesiveness of keratinocytes in sebaceous follicles, which allows for easy removal; has anti-inflammatory properties

            Absorption

            Minimal

            Elimination

            Excretion: Urine (0.1%)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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