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pyrethrins/piperonyl butoxide (OTC)Brand and Other Names:RID Shampoo, Klout Shampoo, more...Pronto Shampoo, RID Mousse, A-200 Shampoo, Tisit Gel, Tisit Lotion, Tisit Shampoo

 
 
 

Dosing & Uses

AdultPediatric

Treatment of Head, Body, Pubic Lice

Apply to affected areas, leave on 10 min & wash

Do not exceed 2 consecutive applications within 24 hr

Retreat in 7-10 days

Amount to apply varies: See package insert

See package insert

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Adverse Effects

Frequency Not Defined

Erythema

Pruritus

Urticaria

Edema

Eczema

Slight corneal erosion

Stromal edema

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Warnings

Contraindications

Hypersensitivity, ragweed (Asteraceae family plants) hypersensitivity

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: no studies

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Absorbed:

Pyrethrins are absorbed through intact skin when applied topically

Piperonyl butoxide reportedly is poorly absorbed through intact skin when applied topically

Mechanism of Action

Following absorption through the chitinous exoskeleton of arthropods, pyrethrins stimulate the nervous system, apparently by competitively interfering with cationic conductances in the lipid layer of nerve cells, thereby blocking nerve impulse transmissions

Piperonyl butoxide has little or no insecticidal activity but potentiates that of pyrethrins by inhibiting the hydrolytic enzymes responsible for pyrethrins' metabolism in arthropods

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