riluzole (Rx)

Brand and Other Names:Rilutek
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 50mg
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Amyotrophic Lateral Sclerosis (ALS)

50 mg PO q12hr on empty stomach

Monitor: LFTs

Huntington Disease (Orphan)

Orphan indication sponsor

  • Rhone-Poulenc Rorer Pharmaceuticals, Inc; 500 Arcola Road, PO Box 5096; Collegeville, PA 19426-0800

Ataxia (Orphan)

Orphan designation for treatment of spinocelebellar ataxia

Sponsor

  • Biohaven Pharmaceutical Holding Company, Ltd; 234 Church Street, Suite 304; New Haven, Connecticut 06511

Amyotrophic Lateral Sclerosis (Orphan)

Oral suspension (Teglutik [brand name]) and orally dissolving tablet: Orphan designation for amyotrophic lateral sclerosis (ALS)

Sponsor

  • Italfarmaco SpA; 54 Via dei Lavoratori; Cinisello Balsamo, Italy

Not recommended

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Interactions

Interaction Checker

and riluzole

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Asthenia (16-20%)

            Nausea (16-20%)

            Skeletal weakness (19%)

            Decreased lung function (11-15%)

            1-10%

            Headache (6-10%)

            Abdominal pain (6-10%)

            Diarrhea (6-10%)

            Dizziness (6-10%)

            Hypertension (6-10%)

            Back pain (1-5%)

            Vomiting (1-5%)

            Anorexia (1-5%)

            Somnolence (1-5%)

            Vertigo (1-5%)

            Circumoral paresthesia (1-5%)

            Arthralgia (1-5%)

            <1%

            Interstitial lung disease and hypersensitivity pneumonitis

            Angioedema

            Bone necrosis

            Edema

            Erythema

            Glaucoma

            Hallucination

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            Warnings

            Contraindications

            Hypersensitivity to drug or any component of the formulation

            Cautions

            Caution in hepatic impairment; not recommended in patients with baseline elevations of serum aminotransferases greater than 5 times upper limit of normal; discontinue therapy if there is evidence of liver dysfunction

            Case reports of clincial hepatitis reported

            Interstitial lung disease reported (upon further investigation, many of these cases were hypersensitivity pneumonitis); discontinue immediately if dry cough or dyspnea develops

            Neutropenia reported; advise patients to report any febrile illness

            Caution in renal impairment

            May cause drowsiness; use caution when performing hazardous tasks requiring alertness

            Sedative effects may be potentiated when used concomitantly with other sedative drugs or ethanol

            Use with caution in the elderly and in females as clearance may be reduced

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown; avoid during breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Benzathiazole; inhibits glutamate release, inactivates voltage-dependent Na+ channels, inhibits effects of excitatory neurotransmitters

            Pharmacokinetics

            Half-Life: 12 hr

            Bioavailability: 60%

            Protein Bound: 96%

            Metabolism: CYP1A2

            Metabolites: 6 major metabolites, some active

            Excretion: Feces (5%); urine (90%)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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