aluminum hydroxide/magnesium hydroxide (OTC)

Brand and Other Names:Maalox
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

aluminum hydroxide/magnesium hydroxide

oral suspension

  • (500mg/500mg)/5mL

oral liquid

  • (200mg/200mg)/5mL
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Gastric Hyperacidity, Heartburn

10-20 mL PO between meals & qHS

Dosage Forms & Strengths

aluminum hydroxide/magnesium hydroxide

oral suspension

  • (500mg/500mg)/5mL

oral liquid

  • (200mg/200mg)/5mL
more...

Gastric Hyperacidity, Heartburn

< 12 years old: Safety & efficacy not established

> 12 years old: 10-20 mL PO between meals & qHS

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Interactions

Interaction Checker

and aluminum hydroxide/magnesium hydroxide

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Aluminum oxide

            • Chalky taste
            • Constipation
            • Fecal impaction
            • Stomach cramps

            Frequency Not Defined

            Aluminum oxide

            • Nausea
            • Vomiting
            • Aluminum intoxication
            • Hypophosphatemia
            • Osteomalacia

            Magnesium oxide

            • Diarrhea
            • Hypermagnesemia
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            Warnings

            Contraindications

            Hypersensitivity to any component

            Cautions

            Renal failure, Mg-restricted diet

            May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Neutralizes gastric acid, increases gastric pH

            Duration

            Fasting: 20-60 min

            1 hr pc: up to 3 hr

            Excretion

            Aluminium oxide: absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminium-containing antacid is absorbed from standard daily doses of antacid), insoluble or poorly absorbed Al salts in the intestines are excreted in the feces

            Magnesium oxide: absorbed Mg ions (up to 30%) are eliminated in urine, unabsorbed drug is excreted in feces

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