minoxidil topical (OTC)Brand and Other Names:Rogaine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical solution

  • 2%
  • 5%

topical foam

  • 5%
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Androgenetic Alopecia

Male: Apply 1 mL of 2% or 5% solution to affected areas of scalp BID (qAM & qHS); no more than 2 ml in 24 hours

Female: Apply 1 mL of 2% solution to affected areas of scalp BID (qAM & qHS)

<18 years old: Safety & efficacy not established

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Adverse Effects

1-10%

Allergic contact dermatitis (7.4%)

Tendonitis (2.6%)

Frequency Not Defined

Irritation

Burning

Erythema at site of application

May see systemic effects (hypotension)

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Warnings

Contraindications

Propylene glycol sensitivity, avoid use with other topical drugs, hypersensitivity

Cautions

Once started, need to use indefinitely; hair growth should be apparent by 4 mth

Can be easily removed from scalp; avoid contact with scalp once applied

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: following topical application of the drug is not known, but the drug has been shown to distribute into milk following oral administration in lactating women

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Absorption: 1.4% systemic, 95% of which is eliminated w/ in 4 d

Mechanism of Action

Acts at the level of the hair follicle, possibly involving direct stimulation of hair follicle epithelial growth

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Images

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