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trospium chloride (Rx)Brand and Other Names:Sanctura, Sanctura XR

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 20mg

capsule, extended release

  • 60mg
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Overactive Bladder

Immediate release: 20 mg PO twice daily

Extended Release: 60 mg PO qDay

Renal Impairment

CrCl <30 mL/min: 20 mg immediate release PO qHS; extended release not recommended

Safety and efficacy not established

>75 years

Immediate release: May titrate down to 20 mg immediated release qDay based on tolerability

Extended release: 60 mg PO qDay

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Interactions

Interaction Checker

trospium chloride and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Dry mouth (20.1%)

            1-10%

            Constipation (9.6%)

            Tachycardia (<2%)

            Headache (4.2%)

            Fatigue (1.9%)

            Rash (<2%)

            Dyspepsia (1-2%)

            Abdominal pain (1-3%)

            Abdominal distention (<2%)

            Constipation (9-10%)

            Dry eyes (1-2%)

            Dyspepsia (1-2%)

            Flatulence (1-2%)

            Urinary retention (<1%)

            Urinary tract infection (1-7%)

            Nasopharyngitis (3%)

            Nasal dryness (1%)

            Postmarketing Reports

            Gastrointestinal: Gastritis

            Cardiovascular: Palpitations, supraventricular tachycardia, chest pain, syncope, hypertensive crisis

            Immunological: Stevens-Johnson syndrome, anaphylactic reaction, angioedema

            Nervous system: Dizziness, confusion, vision abnormal, hallucinations, somnolence and delirium

            Skeletal system: Musculoskeletal: Rhabdomyolysis

            Dermatology: Rash

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            Warnings

            Contraindications

            Urinary/gastric retention

            Uncontrolled narrow-angle glaucoma

            Hypersensitivity

            Cautions

            Controlled narrow-angle glaucoma

            Renal impairment

            Decreased GI motility

            CNS anticholinergic effects reported including dizziness, confusion, hallucinations and somnolence

            Geriatric patients

            Pregnancy/lactation

            Caution with moderate or severe hepatic dysfunction

            Angioedema of the face, lips, tongue and/or larynx reported (including with 1st dose)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in mikl unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Reduces the smooth muscle tone of the bladder by antagonizing the effects of acetyl choline on muscarinic receptors.

            Pharmacokinetics

            Absorption: <10%; reduced when administered with high-fat meal

            Half-life: 20 hr (immediate release)

            Peak plasma time: 5-6 hr

            Protein bound: 45-85%

            Metabolism: Not fully elucidated; major pathway is thought to be ester hydrolysis followed by glucuronide conjugation of benzylic acid

            Renal clearance: 29.07 L/hr

            Excretion: Feces (85.2%); urine (5.8% with 60% unchanged drug)

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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