octreotide (Antidote) (Rx)

Brand and Other Names:Sandostatin (Antidote)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable

  • 50mcg/mL
  • 100mcg/mL
  • 200mcg/mL
  • 500mcg/mL
  • 1000mcg/mL
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Sulfonylurea Overdose

Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")

50-100 mcg SC/IV BID/TID, adjust according to blood glucose

For IV, dilute in 50 mL 0.9% NaCl or D5W and infuse over 15-30 minutes (may be given IV push over 3 minutes)

Dosage Forms & Strengths

injectable

  • 50mcg/mL
  • 100mcg/mL
  • 200mcg/mL
  • 500mcg/mL
  • 1000mcg/mL
more...

Sulfonylurea Overdose

Used for sulfonylurea overdoses when more than 1-2 boluses of D50W are ineffective to control hypoglycemia (will be "glucose sparing")

Not well-established

1 mcg/kg SC q12hr OR 4-5 mcg/kg/day divided QID SC  

Severe refractory cases, start continuous IV infusion at 15 ng/kg/min and titrate to response

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Interactions

Interaction Checker

and octreotide (Antidote)

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Conduction abnormalities

            CHF

            Dizziness

            Fatigue

            Headache

            Diarrhea

            Nausea

            Pain at injection site

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            Pregnancy & Lactation

            Pregnancy Category: B

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            An analogue of somatostatin

            Antagonizes pancreatic insulin release

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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