Brand and Other Names:schisandra chinensis, wu wei zi, more...schizandra, schisandra sphenanthera
- Classes: Antimicrobials, Herbals
Concentration, Coordination, & Endurance
1.5-6 g/day fruit PO, OR
500-2000 mg/day standardized extract PO
20 mg lignan content/day (equivalent to 1.5 g crude schisandra)
Standardized to minimum 1.3% lignan content
Adaptogen; immunostimulant; viral- or drug-induced hepatitis treatment
Thought to lower LFTs in hepatitis, and improving concentration, coordination, & endurance
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Minor GI disturbances
Pregnancy & Lactation
Pregnancy Category: X
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Increase hepatic glutathione, glucose-6-phosphate
Inhibits CYP3A and P-gp metabolic enzymatic pathways