cycloserine (Rx)

Brand and Other Names:Seromycin
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 250mg
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Active Tuberculosis

Initial: 250 mg PO q12hr for 14 days THEN

500 mg -1 g/day divided q12hr for 18-24 months; not to exceed 1 g/day

Monitor blood levels

UTI

Initial: 250 mg PO q12hr for first 14 days

Maintenance: 500 mg -1 g/day in divided doses; not to exceed 1 g/day

Monitor blood levels

Gaucher's Disease (Orphan)

Orphan indication sponsor

  • Lev, Meir M.D.; The City College, City University Of NY Medical Sc, Convent Avenue at 138 Street; New York, NY 10031

Renal Impairment

CrCl 50-80 mL/min: Administer q12-16hr

CrCl 10-49 mL/min: Administer q24-36hr

CrCl <10 mL/min: Administer q36-48hr

Administration

Part of multi-drug regimen; not first-line treatment

Dosage Forms & Strengths

capsule

  • 250mg
more...

Active Tuberculosis

10-20 mg/kg/day PO in divided doses up to 1 g/day for 18-24 months 

Renal Impairment

CrCl 50-80 mL/min: Administer q12-16hr

CrCl 10-49 mL/min: Administer q24-36hr

CrCl <10 mL/min: Administer q36-48hr

Administration

Part of multi-drug regimen; not first-line treatment

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Interactions

Interaction Checker

and cycloserine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Confusion

            Restlessness

            Drowsiness

            Vertigo

            Cardiac arrhythmia

            Folate deficiency

            Hyperreflexia

            Dysarthria

            Dizziness

            Headache

            Coma

            Liver enzymes increased

            Somnolence

            Paresis

            Seizure

            Heart failure

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            Warnings

            Contraindications

            Hypersensitivity

            Alcohol use

            Renal dysfunction, severe

            History of seizure disorder, mental depression, severe anxiety or psychosis

            Cautions

            Caution in patients with history of alcoholism (may increase seizures), anemia, impaired hepatic/renal function

            CNS toxicity (depression, seizures, psychosis) may occur

            Prolonged use may result in fungal or bacterial superinfection (C. difficile-associated diarrhea)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: enters breast milk; safe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Bacteriostatic or bactericidal

            Inhibits cell wall synthesis

            Pharmacokinetics

            Absorption: 70-90%

            Metabolism: Hepatic

            Half-life: 10 hr (normal renal function)

            Peak plasma serum: 4-8 hr

            Excretion: Urine (60 to 70%)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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