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reserpine (Rx)Brand and Other Names:Serpasil

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 0.1mg
  • 0.25mg
more...

Hypertension

Initial

  • 0.5 mg daily for 1 or 2 weeks

Maintenance

  • 0.1-0.25 mg PO qDay
  • Use higher dosages cautiously occurrence of mental depression or other adverse reactions may increase

Psychiatric Disorders

0.5 mg daily, but may range from 0.1 to 1 mg

Dosage Forms & Strengths

tablet

  • 0.1mg
  • 0.25mg
more...

Hypertension

0.02 mg/kg/d POqD or div BID, no more than 0.25 mg/d 

Adverse CNS effects; may cause bradycardia and orthostatic hypotension; not recommended as routine treatment for hypertension (Beers criteria)

0.05 mg PO qDay; may increase by 0.05 mg after 1 week as needed; not to exceed 0.1 mg/day

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Interactions

Interaction Checker

reserpine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Angina

            Bradycardia

            Syncope

            Dizziness

            Depression

            Lethargy

            Nightmare

            Tardive dyskinesia

            GI hypersecretion

            Impotence

            Nasal congestion

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            Warnings

            Contraindications

            Hypersensitivity, active peptic ulcer, ulcerative colitis, history of depression, history of gallstones; electroconvulsive treatment within 1 week

            MAOIs: discontinue several days before starting reserpine therapy

            Avoid during breast-feeding

            Cautions

            Asthma

            History of gall stones, PUD, ulcerative colitis

            Breastfeeding

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unsafe; excreted into breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Peripheral adrenergic neuron antagonist via depletion of tissue store of catecholamines resulting in bradycardia

            Absorption

            Bioavailability: 30-40%

            Duration: 1-6 wk

            Distribution

            Protein binding: 96%

            Metabolism

            Extensively metabolized in the liver

            Metabolites: trimethylbenzoic acid, methyl reserpate (inactive)

            Elimination

            Half-Life: 50-100 hr

            Excretion: Feces 60%; urine 12%

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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