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metaxalone (Rx)Brand and Other Names:Skelaxin

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 800mg
more...

Acute Painful Musculoskeletal Conditions

800 mg PO q6-8hr

Systemic Sclerosis (Orphan)

Uvadex

In conjunction with the UVAR photopheresis to treat diffuse systemic sclerosis

Orphan indication sponsor

  • Therakos, Inc; Oaklands Corporate Center; 437 Creamery Way; Exton, PA 19341

Cardiac Allograft Rejection (Orphan)

Uvadex

Prevention of acute rejection of cardiac allografts

Orphan indication sponsor

  • Therakos, Inc; Oaklands Corporate Center; 437 Creamery Way; Exton, PA 19341

Dosing Modifications

Renal impairment

  • Mild to moderate impairment: Use caution
  • Severe impairment: Contraindicated

Hepatic impairment

  • Mild to moderate impairment: Use caution
  • Severe impairment: Contraindicated

Dosage Forms & Strengths

tablet

  • 800mg
more...

Musculoskeletal Pain

<12 years: Safety and efficacy not established

>12 years: 800 mg PO q6-8hr

Systemic Sclerosis (Orphan)

Uvadex

In conjunction with the UVAR photopheresis to treat diffuse systemic sclerosis

Orphan indication sponsor

  • Therakos, Inc; Oaklands Corporate Center; 437 Creamery Way; Exton, PA 19341

Cardiac Allograft Rejection (Orphan)

Uvadex

Prevention of acute rejection of cardiac allografts

Orphan indication sponsor

  • Therakos, Inc; Oaklands Corporate Center; 437 Creamery Way; Exton, PA 19341
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Interactions

Interaction Checker

metaxalone and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Drug-induced gastrointestinal disturbance

            Nausea

            Vomiting

            Dizziness

            Headache

            Somnolence

            Nervousness

            Hemolytic anemia (rare)

            Leukopenia (rare)

            Jaundice (rare)

            Immune hypersensitivity reaction (rare)

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            Warnings

            Contraindications

            Hypersensitivity

            History of drug-induced hemolytic anemia

            Significant renal/hepatic impairment

            Cautions

            CNS depression may occur

            Sedative effects may be potentiated when used with other sedatives

            Medication is poorly tolerated by the elderly

            Bioavailability may increase in female patients

            Use caution in renal and hepatic impairment

            Safety and efficacy not established in children <12 years

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Unknown if excreted in breast milk; not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            General CNS depression; no direct effect on skeletal muscle; may disrupt the spasm-pain-spasm cycle; does not havae direct effect on skeletal muscle

            Absorption

            Onset: Within 1 hr

            Duration: 4-6 hr

            Peak plasma time: 3 hr

            Peak plasma concentration: 296 mcg/mL

            Distribution

            Vd: 800 L

            Metabolism

            Liver

            Metabolites: Unidentified

            Elimination

            Half-life elimination: 4-14 hr

            Excretion: Urine

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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