mequinol/tretinoin (Discontinued)

Brand and Other Names:Solage
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

mequinol/tretinoin

topical solution

  • (2%/0.01%)
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Dermatologic Conditions

Apply to affected area qHS or evening

Other Indications & Uses

Solar lentigines

Dosage Forms & Strengths

mequinol/tretinoin

topical solution

  • (2%/0.01%)
more...

Acne Vulgaris

<12 years old: Safety & efficacy not established

>12 years old: Apply to affected area qHS or evening

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Interactions

Interaction Checker

and mequinol/tretinoin

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Erythema (49%)

            Peeling of skin (14%)

            Pruritus (12%)

            1-10%

            Skin hypopigmented (5%)

            Sensation of burning of skin

            Stinging of skin

            Tingling of skin

            Application site reaction

            Crusting

            <1%

            Phototoxicity

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            Warnings

            Contraindications

            Hypersensitivity

            Pregnancy, women of childbearing potential

            Children

            Cautions

            Pts with moderately or heavily pigmented skin

            Works gradually

            Do not use larger than recommended amounts

            May exacerbate vitiligo

            Minimize exposure to sunlight or sunlamps

            Discontinue if sensitivity develops

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Peak Plasma: Mequinol: 10 ng/mL

            Metabolism: N/A

            Excretion: urine & feces

            Mechanism of Action

            Mequinol: depigmenting agent

            Tretinoin: may repair skin damage due to UV radiation

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            Images

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