Brand and Other Names:Sonata
- Classes: Sedative/Hypnotics
Dosing & Uses
Dosage Forms & Strengths
capsule: Schedule IV
Insomnia (Short-term Use)
10-20 mg PO qHS, range 5-20 mg/day
Mild to moderate impairmet: No dose adjustment necessary
Severe impairment: Not studied
Mild to moderate impairment: 5 mg at bedtime
Severe impairment: Not recommended
5 mg PO qHS; not to exceed 10 mg/day
Serious - Use Alternative
Significant - Monitor Closely
Abdominal pain (6%)
Eye pain (3-4%)
Anaphylactic/anaphylactoid reactions, including severe reactions
Severe hepatic impairment
May impair ability to perform hazardous tasks
Depression, hepatic impairment
Amnesia may occur
Sleep related activities may occur
Use caution in patients respiratory diseases or patients experiencing clinical depression (condition may worsen)
Effects of other CNS depressants being taken concurrently may be potentiated
Pregnancy & Lactation
Pregnancy Category: C
Lactation: small amount secreted in breast milk, not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Pyrazolopyrimidine; GABA-BZD receptor complex agonist
Half-life elimination: 1 hr
Duration: Shorter than zolpidem
Peak Plasma Time: 1 hr
Bioavailability: 30% (undergoes extensive presystemic metabolism)
Protein Bound: 45-75%
Vd: 1.4 L/kg
Metabolism: mostly by aldehyde oxidase; some by CYP3A4
Total Body Clearance: 3 L/hr/kg
Excretion: urine 70%; feces 17%
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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