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nateglinide (Rx)Brand and Other Names:Starlix

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 60mg
  • 120mg
more...

Type 2 DM Monotherapy, or With Metformin

120 mg PO q8hr; 60 mg PO q8hr if patient near goal HbA1C

Take dose 1-30 minutes before meal

Safety & efficacy not established

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Interactions

Interaction Checker

nateglinide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Increased uric acid (10%)

            Dizziness (4%)

            Arthropathy (3%)

            Flu-like syndrome

            Weight gain

            Hypoglycemia (2%)

            Frequency Not Defined

            Diarrhea

            Nausea

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            Warnings

            Contraindications

            Documented hypersensitivity

            Diabetic ketoacidosis, type I DM

            Cautions

            Patients with risk of severe hypoglycemia: elderly, malnourished, adrenal or pituitary insufficiency, hepatic insufficiency

            Patients with stress due to infection, fever, trauma, or surgery

            Not to be used in combination with an insulin secretagogue (eg, glyburide)

            Not to be used as substitute for metformin monnotherapy but as adjunctive

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unsafe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Increases insulin secretion via binding K+ channels on beta islet cells. Reduces postprandial hyperglycemia. Amount of insulin released is dependent upon existing glucose levels.

            Half-Life

            1.2-3 hr

            Duration

            4 hr

            Onset

            Initial effect: 15 min

            Max effect: 1-2 hr

            Excretion

            Urine:83%

            Feces: 10%

            Distribution

            10 L

            Other Information

            Peak Plasma Time: < 1hr

            Bioavailability: 72-75%

            Protein Bound: 97-99%

            Metabolism: by hepatic cytochrome P450 CYP2C9 (70%) & CYP3A4 (30%)

            Metabolites: major metabolite M1 (20% potency of parent drug), & many other metabolites

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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