250-500 mg PO TID
1 g stevioside take with meals
Water extracts of 5 g of leaves q 6hr x 3 days to increase glucose tolerance
Non-caloric sweetener for foods/beverages
Hyperglycemia, weight loss aid, diuretic, & hypertension
Studies inconclusive and contradictory
Serious - Use Alternative
Significant - Monitor Closely
Hypersensitivity to Asteraceae family (ragweed, daisies, etc)
FDA, WHO, European regulatory agencies have questioned safety of chronic use
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Stevioside 100x sweeter than sucrose
Stevioside, steviol may decr GI absorption of glucose and stimulate insulin secretion