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ivermectin (Rx)Brand and Other Names:Stromectol

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 3mg
more...

Strongyloidiasis of the Intestinal Tract

15-24 kg: 3 mg PO once

25-35 kg: 6 mg PO once

36-50 kg: 9 mg PO once

51-65 kg: 12 mg PO once

66-79 kg: 15 mg PO once

>80 kg: 200 mcg/kg PO once 

Dosing considerations

  • In general repeat doses not necessary; perform stool examinations to verify eradication of infection

River Blindness (Onchocerciasis)

15-25 kg: 3 mg PO; may repeat in 3-12 mo

26-44 kg: 6 mg PO; may repeat in 3-12 mo

45-64 kg: 9 mg PO; may repeat in 3-12 mo

65-84 kg: 12 mg PO; may repeat in 3-12 mo

≥85 kg: 150 mcg/kg PO; may repeat in 3-12 mo 

Dosing considerations

  • Note: Does not treat adult worms (must be surgically excised)

Head Lice (Pediculosis capitis; Off-label)

200 mcg/kg PO once; may require 1-2 additional doses repeated after 7 days 

Blepharitis (Demodex folliculorum; Off-label)

200 mcg/kg PO once as a single dose, THEN repeat dose once in 7 days 

Filariasis Due to Mansonella Ozzardi (Off-label)

6 mg PO as single dose

Filariasis Due to Mansonella Streptocera (Off-label)

150 mcg/kg as single dose

Scabies Due to Sarcoptes Scabiel

Immunocompromised patients: 200 mcg/kg as single dose; may repeat in 14 days if necessary

Gnathostoma Spinigerum

Gnathostomiasis: 200 mcg/kg as single dose

Administration

Take on empty stomach

Monitor: Stool exams (Strongyloides)

Dosage Forms & Strengths

tablet

  • 3mg
more...

River Blindness (Onchocerciasis)

<15 kg: Safety and efficacy not established

15-25 kg: 3 mg PO; may repeat in 3-12 mo

26-44 kg: 6 mg PO; may repeat in 3-12 mo

45-64 kg: 9 mg PO; may repeat in 3-12 mo

65-84 kg: 12 mg PO; may repeat in 3-12 mo

≥85 kg: 150 mcg/kg PO; may repeat in 3-12 mo 

Dosing considerations

  • Note: Does not treat adult worms (must be surgically excised)

Strongyloidiasis of the Intestinal Tract

<15 kg: Safety and efficacy not established

15-24 kg: 3 mg PO once

25-35 kg: 6 mg PO once

36-50 kg: 9 mg PO once

51-65 kg: 12 mg PO once

66-79 kg: 15 mg PO once

>80 kg: 200 mcg/kg PO once 

Dosing considerations

  • In general repeat doses not necessary; perform stool examinations to verify eradication of infection

Administration

Take on empty stomach

Monitor: Stool exams (Strongyloides)

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Interactions

Interaction Checker

ivermectin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal pain

            Asthenia

            Hypotension

            Mild EKG changes

            Peripheral & facial edema

            Transient tachycardia

            Dizziness

            Headache

            Hyperthermia

            Insomnia

            Somnolence

            Vertigo

            Pruritus

            Rash

            Urticaria

            Diarrhea

            Nausea

            Vomiting

            Eosinophilia

            Leukopenia

            ALT/AST increased

            Limbitis

            Myalgia

            Tremor

            Blurred vision

            Mild conjunctivitis

            Punctate opacity

            Mazzotti reaction (with onchocerciasis)

            Edema

            Fever

            Lymphadenopathy

            Ocular damage

            Pruritus rash

            Conjunctival hemorrhage (with onchocerciasis)

            Hepatitis

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            Warnings

            Contraindications

            Hypersensitivity to ivermectin

            Cautions

            May cause cutaneous and/or systemic reactions

            Does not kill adult Onchocerca volvulus, only microfilariae

            Not active against disseminated Strongyloides, only intestinal

            Potential risk of Mazzotti reactions (cutaneous and systemic adverse effects)

            May be required to repeat treatments in immunocompromised patients

            Suppressive therapy (monthly) may be necessary to control extraintestinal strongyloidiasis

            Perform pretreatment assessment for Loa loa infection in any patient with significant exposure to endemic areas; serious and/or fatal encephalopathy reported during treatment in patients with loiasis

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Enters breast milk (AAP Committee states compatible with nursing)

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Binds glutamate-gated Cl ion channels in invertebrate nerve and muscle cells; produces paralysis, death of parasite

            Absorption

            Well absorbed

            Peak serum time: 4 hr

            Peak effect: 3-6 months (treatment of orchocerciasis); 3 months (treatment of strongyloides)

            Distribution

            Protein bound: 93%

            Vd: 3-3.5 L/kg

            Does not cross blood-brain barrier

            Metabolism

            Hepatic (CYP3A4, CYP2D6, CYP2E1)

            Elimination

            Half-life: 18 hr

            Excretion: Feces; urine (<1%)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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