chlorpheniramine/pseudoephedrine (OTC)

Brand and Other Names:Sudafed Sinus and Allergy, Allerest Maximum Strength and Hay Fever, more...A.R.M.
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

chlorpheniramine/pseudoephedrine

liquid

  • (2mg/30mg)/5mL

liquid drops

  • (0.8mg/9mg)/1mL

tablet

  • 4mg/60mg

chewable tablet

  • 2mg/30mg
more...

Rhinitis/Decongestant

Liquid: 10mL PO q4-6hr; not to exceed 60mL/24hr

Chewable tablet: 2 tabs PO q4-6hr; not to exceed 8 tabs/24hr

Tablet: 1 tab PO q4-6hr; not to exceed 4 tabs/24hr

Dosage Forms & Strengths

chlorpheniramine/pseudoephedrine

liquid

  • (2mg/30mg)/5mL

liquid drops

  • (0.8mg/9mg)/1mL

chewable tablet

  • 2mg/30mg

tablet

  • 4mg/60mg
more...

Rhinitis/Decongestant

<6 Years Old

  • Ask a pediatrician

6-12 Years Old

  • Liquid drops: 2 mL PO q4-6hr; not to exceed 8 mL/24hr
  • Liquid: 5 mL PO q4-6hr; not to exceed 30 mL/24hr
  • Chewable tablet: Chlorpheniramine maleate 2 mg and pseudoephedrine HCl 30 mg PO q4-6hr
  • Tablet: One half tablet PO q4-6hr; not to exceed 2 tabs/24hr

>12 Years Old

  • Liquid: 10mL PO q4-6hr; not to exceed 60mL/24hr
  • Chewable tablet: 2 tabs PO q4-6hr; not to exceed 8 tabs/24hr
  • Tablet: Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr
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Interactions

Interaction Checker

and chlorpheniramine/pseudoephedrine

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Adverse Effects

            Frequency Not Defined

            Arrhythmia

            Hypotension

            Palpitations

            Tachycardia

            Confusion

            Convulsion

            Depression

            Distress

            Dizziness

            Drowsiness

            Excitability

            Euphoria

            Fatigue

            Headache

            Insomnia

            Irritability

            Sedation

            Tremors

            Weakness

            Anorexia

            Agranulocytosis

            Hemolytic anemia

            Thrombocytopenia

            Thickening of bronchial secretions

            Wheezing

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            Warnings

            Contraindications

            Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, cardiovascular disease, bladder-neck obstruction, and stenosing peptic ulcer

            Cautions

            Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine

            Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: enters breastmilk/contraindicated

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.

            Pseudoephedrine is a sympathomimetic; exerts decongestant action on nasal mucosa; stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.

            Pharmacokinetics

            Chlorpheniramine

            • Vd: 4-7 L/kg (children); 6-12 L/kg (adults)
            • Protein binding: 33%
            • Half-life: 10-13 hr (children); 14-24 hr (adults)
            • Peak plasma time: 2-4 hr
            • Excretion: Urine

            Pseudoephedrine

            • Half-Life: 3 hr (children); 3-16hr (adults)
            • Onset: 30 min
            • Absorption: Rapid
            • Duration: 3-8 hr
            • Peak Plasma Time: 1-3 hr (adults); 2hr (children)
            • Peak Plasma Concentration: 422 ng/mL
            • Clearance:  7.3-7.6 mL/min/kg
            • Excretion: Urine
            • Vd: 2.5 L/kg (children); 2.64-3.51 L/kg (adults)
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            Images

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