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mafenide (Rx)Brand and Other Names:Sulfamylon

 
 
 

Dosing & Uses

AdultPediatric

Burn Treatment

Cream

  • Apply to cleaned, debrided area qD-BID at thickness ~1/16 inch
  • Ensure burned area covered with cream at all times-reapply PRN

Topical solution

  • Cover grafted area with 1 layer of gauze
  • Wet 8-ply burn dressing w/ soln until leakage observed; apply, secure & wrap as necessary
  • With irrigation tubing: keep gauze dressing wet, by irrigating with syringe or injecting solution into irrigation tubing q4hr or PRN
  • Not using irrigation tubing: moisten gauze q6-8hr or PRN
  • Wound dressings may be left undisturbed for up to 5 d

Other Indications & Uses

Prevention of septicemia (esp by Pseudomonas aeruginosa) following 2nd/3rd degree burns

Burn Treatment

Cream

  • <2 yo: Safety & efficacy not established
  • >2 yo: Apply to cleaned, debrided area qD-BID at thickness ~1/16 inch; ensure burned area covered with cream at all times-reapply PRN

Topical solution

  • Cover grafted area with 1 layer of gauze
  • Wet 8-ply burn dressing with soln until leakage observed; apply, secure & wrap as necessary
  • With irrigation tubing: keep gauze dressing wet, by irrigating with syringe or injecting solution into irrigation tubing q4hr or PRN
  • Not using irrigation tubing: moisten gauze q6-8hr or PRN
  • Wound dressings may be left undisturbed for up to 5 d
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Adverse Effects

Frequency Not Defined

Application site rxns

Allergic rxns

Systemic acidosis w/ tachypnea

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Warnings

Cautions

Hypersensitivity

ARF, lung problems, blood dyscrasias

E. coli & Proteus spp. appear to be less sensitive

Pregnancy/women of childbearing potential-not recommended in women of childbearing potential unless burned area >20% BSA or benefits justify possible risks to the fetus

G-6-PD deficiency; may result in hemolytic anemia

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known whether distributed into breast milk, discontinue drug or do not nurse

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Absorption: yes

Metabolism: rapidly to p-carboxybenzenesulfonamide

Excretion: p-carboxybenzenesulfonamide in urine, mafenide undetected in urine

Mechanism of Action

Bacteriostatic, precise mechanism unclear-appears to interfere w/ bacterial metabolism

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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