Brand and Other Names:Syprine
- Classes: Copper Chelators
Dosing & Uses
Dosage Forms & Strengths
For patients intolerant of penicillamine
750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day
Indicated for the treatment of manganism
Orphan indication sponsor
- Biovail Technologies, Ltd; 700 Route 202/206 North; Bridgewater, NJ 08807
Wilson Disease (Orphan)
New salt form: trientine tetrahydrochloride
Orphan designation for treatment of Wilson Disease
- GMP-Orphan SAS; Voisin Consulting, Inc; 222 Third Street, Suite 3121; Cambridge, Massachusetts 02142
Dosage Forms & Strengths
- 500-750 mg/day PO divided q6-12hr; not to exceed 1.5 g/day
- For patients intolerant of penicillamine: 750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Rash; thickening and fissuring of skin
Loss of taste
Lupus like eruption
Hypersensitivity to product or components
Not indicated for cystinuria, RA (cf penicillamine) or biliary cirrhosis
May cause iron deficiency anemia
Hepatic iron oveload may result from copper deficiency induced by therapy
Monitor urinary copper and for signs of hypersensitivity (eg, elevated body temperature)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretioin in breast milk unknown; use caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Oral chelating agent used to induce adequate cupriuresis
Excretion: Urine (9%)
Take on empty stomach 1 hr before or 2 hr after meals
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
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|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
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