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trientine (Rx)Brand and Other Names:Syprine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 250mg
more...

Wilson Disease

For patients intolerant of penicillamine

750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day

Manganism (Orphan)

Indicated for the treatment of manganism

Orphan indication sponsor

  • Biovail Technologies, Ltd; 700 Route 202/206 North; Bridgewater, NJ 08807

Wilson Disease (Orphan)

New salt form: trientine tetrahydrochloride

Orphan designation for treatment of Wilson Disease

Sponsor

  • GMP-Orphan SAS; Voisin Consulting, Inc; 222 Third Street, Suite 3121; Cambridge, Massachusetts 02142

Dosage Forms & Strengths

capsule

  • 250mg
more...

Wilson Disease

<12 years

  • 500-750 mg/day PO divided q6-12hr; not to exceed 1.5 g/day

≥12 years

  • For patients intolerant of penicillamine: 750-1250 mg/day PO divided q6-12hr; not to exceed 2 g/day
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Interactions

Interaction Checker

trientine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Dystonia

            Iron deficiency

            Rash; thickening and fissuring of skin

            Muscular spasm

            Myasthenia gravis

            SLE

            Abdominal pain

            Gastritis

            Aphthoid ulcer

            Anorexia

            Colitis

            Heartburn

            Loss of taste

            Aplastic anemia

            Sideroblastic anemia

            Lupus like eruption

            Myasthenia gravis

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            Warnings

            Contraindications

            Hypersensitivity to product or components

            Cautions

            Not indicated for cystinuria, RA (cf penicillamine) or biliary cirrhosis

            May cause iron deficiency anemia

            Hepatic iron oveload may result from copper deficiency induced by therapy

            Monitor urinary copper and for signs of hypersensitivity (eg, elevated body temperature)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretioin in breast milk unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Oral chelating agent used to induce adequate cupriuresis

            Pharmacokinetics

            Absorption: Poor

            Excretion: Urine (9%)

            Metabolite: Acetyltrien

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            Administration

            Oral Administration

            Take on empty stomach 1 hr before or 2 hr after meals

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Select a class to view formulary status for similar drugs

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