calcipotriene/betamethasone (Rx)

  • Print
Brand and Other Names:Taclonex Ointment, Enstilar, more...Taclonex Topical Suspension

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

calcipotriene/betamethasone

topical ointment

  • 0.005%/0.064%

topical suspension

  • 0.005%/0.064%

topical foam (Enstilar)

  • 0.005%/0.064%
more...

Plaque Psoriasis

Suspension (scalp and body): Apply to affected area(s) qDay for up to 8 weeks; may discontinue treatment earlier, if cleared; not to exceed 100 g/week

Ointment: Apply topical layer of ointment to affected area(s) qDay for up to 4 weeks; do not exceed 100 g/week

Foam: Apply topically to affected area(s) qDay for up to 4 weeks

Dosage Forms & Strengths

calcipotriene/betamethasone

topical suspension

  • 0.005%/0.064%
more...

Plaque Psoriasis

Indicated for plaque psoriasis of the scalp

<12 years: Safety and efficacy not established

Suspension (12-17 years): Apply to affected area(s) qDay for up to 8 weeks; may discontinue treatment earlier, if cleared; do not exceed 60 g/week

Next:

Interactions

Interaction Checker

and calcipotriene/betamethasone

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            1-10%

            Pruritus (7.2%)

            Worsening psoriasis (3.4%)

            Skin atrophy (1.9%)

            Folliculitis (1.4%)

            Burning sensation (1.4%)

            Skin depigmentation (1.4%)

            Ecchymosis (1%)

            Erythema (1%)

            Hand dermatitis (1%)

            Previous
            Next:

            Warnings

            Contraindications

            Hypersensitivity

            Known or suspected disorders of calcium metabolism

            Erythrodermic, exfoliative, and/or pustular psoriasis

            Cautions

            Hypercalcemia observed with use of calcipotriene

            Discontinue if irritation develops

            Do not apply to on face, axillae, or groin

            Do not apply to areas of pre-existing skin atrophy

            If concomitant skin infection present/develops, apply appropriate antifungal or antibacterial agent

            Systemic absorption of topical corticosteroids

            • Avoid application over large surface areas, prolonged use, and occlusive dressings that may increase risk for corticosteroid adverse effects
            • Pediatric patients are at a greater risk than adults of systemic toxicity when treated with topical drugs and at greater risk of HPA axis suppression and adrenal insufficiency upon topical corticosteroid use
            • Excessive systemic absorption may cause HPA axis suppression, Cushing syndrome, hyperglycemia, glucosuria
            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unknown whether distributed in breast milk, safety during breast feeding not established

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Calcipotriene: In vitro evidence suggests drug is roughly equipotent to natural vitamin D in its effects on proliferation & differentiation of various cell types

            Betamethasone: Corticosteroid; elicits anti-inflammatory, antipruritic, and vasoconstrictive properties

            Previous
            Next:

            Administration

            Instructions

            Do not apply to face, axillae, or groin, or if skin atrophy is present at treatment site

            Wash hands after application

            Topical ointment

            • Rub ointment into skin gently and completely
            • Do not treat >30% of body surface area

            Topical suspension

            • Shake bottle prior to use
            • Do not use with occlusive dressings unless directed by a physician
            Previous
            Next:

            Images

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous