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pentazocine (Rx)Brand and Other Names:Talwin

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable solution: Schedule IV

  • 30mg/mL
more...

Treatment of Moderate to Severe Pain

30 mg IV/IM/SC q3-4hr (not to exceed 30 mg/dose IV or 60 mg/dose IM/SC)

Not to exceed 360 mg/day IV/IM/SC

Labor Pain

30mg IM once OR

20mg IV when contractions become regular; may give q2-3hr PRN; not to exceed 60 mg

Preoperative or Preanesthetic/Supplement to Surgical Anesthesia

30 mg IV/IM/SC q3-4hr (not to exceed 30 mg/dose IV or 60 mg/dose IM/SC)

Not to exceed 360 mg/day IV/IM/SC

Renal Impairment

CrCl 10-50 mL/min: 75% of regular dose

CrCl<10 mL/min: 50% of regular dose

Hepatic Impairment

Use lower dose or avoid in liver disease

See Also Combos With

Acetaminophen: Talacen

ASA: Talwin Compound (discontinued)

Naloxone (Talwin Nx)

Pentazocine HCl tablets (Talwin 50) (discontinued)

Dosage Forms & Strengths

injectable solution: Schedule IV

  • 30mg/mL
more...

Preoperative or Preanesthetic/Supplement to Surgical Anesthesia

>1 year: 0.5 mg/kg IM as a single dose 

Analgesia (Off-label)

<5 years: Safety and efficacy not established

5-8 years: 15 mg IM

>8 years: 30 mg IM

Treatment of moderate to severe pain

30 mg IV/IM/SC q3-4hr (not to exceed 30 mg/dose IV or 60 mg/dose IM/SC)

Not to exceed 360 mg/day IV/IM/SC

Preoperative or preanesthetic/supplement to surgical anesthesia

30 mg IV/IM/SC q3-4hr (not to exceed 30 mg/dose IV or 60 mg/dose IM/SC)

Not to exceed 360 mg/day IV/IM/SC

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Interactions

Interaction Checker

pentazocine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Nausea

            Vomiting

            Constipation

            Abdominal distress

            Cramps

            Anorexia

            Diarrhea

            Diaphoresis, flushed skin (including plethora)

            Rash, pruritus, urticaria

            Edema of the face

            Dizziness

            Lightheadedness

            Euphoria

            Sedation

            Nervousness

            Apprehension

            Depression

            Floating feeling

            Headache

            Weakness or faintness

            Disturbed dreams

            Insomnia

            Syncope

            Tachycardia

            Circulatory depression

            Shock

            Increased blood pressure

            Stinging

            Soft tissue induration, nodule

            Cutaneous depression

            Ulceration

            Severe sclerosis of the skin

            Depression of leukocytes (especially granulocytes)

            Moderate transient eosinophilia

            Blurred vision

            Focusing difficulty

            Nystagmus

            Diplopia

            Miosis

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            Warnings

            Contraindications

            Toxin-mediated diarrhea, pseudomembranous enterocolitis, respiratory depression

            Cautions

            Acute asthma, bradycardia, chronic respiratory disease, head injury, inflammatory bowel disease, intracranial HTN, acute abdominal pain, BPH, biliary spasm, cardiac conduction disorder, liver disease, drug dependence, epilepsy, gallbladder disease, hypotension, hypothyroidism, mood changes, urinary system procedure, renal disease, substance abuse, urethral stricture

            Less risk of respiratory sedation than with pure opioid agonist (dose dependent); highest incidence of psychotomimetic effects of all opioid agonist/antagonists

            May produce withdrawal in opioid dependent pts

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            Pregnancy & Lactation

            Pregnancy Category: C; D if used for prolonged periods or near term

            Lactation: unknown if excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Opioid agonist; inhibits ascending pain pathways, which causes alteration in response to pain; produces analgesia, respiratory depression, and sedation  

            Pharmacokinetics

            Half-life: 2-3 hr

            Onset: IM 15-20 min; IV 2-3 min

            Duration: IM 2 hr; IV 1 hr

            Peak Plasma Time: IM 15-60 min; IV 15 min

            Concentration: IM 140 ng/mL

            Bioavailability: 60-70%

            Protein Bound: 60%

            Metabolism: liver, (oxidation of terminal methyl groups-dimethyl alkyl side chain); glucuronide conjugation

            Metabolites: Alcoholic/carboxylic acid metabolites

            Excretion: Urine (mainly); feces

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            Administration

            IV Incompatibilities

            Additive: aminophylline, amobarbital, pentobarbital, phenobarbital, sodium bicarbonate

            Syringe: glycopyrrolate, heparin, pentobarbital

            Y-site: nafcillin

            IV Compatabilities

            Syringe: atropine, butorphanol, chlorpromazine, cimetidine, dimenhydrinate, diphenhydramine, droperidol, fentanyl, glycopyrrolate, hydromorphone, hydroxyzine, meperidine, meperidine w/ perphenazine, metoclopramide, morphine, papaveretum, perphenazine, prochlorperazine, promazine, promethazine, ranitidine, scopolamine

            Y-site: heparin, hydrocortisone Na-succinate, KCl, Vit B/C

            IV/IM Administration

            IM, SC, & IV

            Constant rotation of injection site for IM necessary

            Use SC route only when necessary due to tissue damage

            Avoid intra-arterial injection

            Storage

            Store at room temp

            Protect from heat & freezing

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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