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timolol ophthalmic (Rx)Brand and Other Names:Timoptic, Timoptic in Ocudose, more...Timoptic XE, Tim Ak, Betimol, Istalol

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.25%
  • 0.5%

gel forming solution

  • 0.25%
  • 0.5%
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Other Indications & Uses

Open-angle glaucoma

1 gtt affected eye(s) BID 0.25%, if not effective increase 0.5% 1 gtt BID

XE formulation: 1 gtt qDay

See also combo

  • with dorzolamide (Cosopt)
  • with latanoprost (Xalacom-Canadian)
  • with brimonidine (Combigan-Canadian)

Safety & efficacy not established

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Adverse Effects

>10%

Blurred vision lasting 0.5-5 min (33%)

Burning or stinging (13%)

Frequency Not Defined

Ocular irritation

Conjunctivitis

Blepharitis

Keratitis

Ocular pain

Discharge (e.g., crusting)

Itching & tearing

Foreign body sensation

Dry eyes

Eyelid erythema

Blepharoptosis

Decreased corneal sensitivity

Diplopia

Cystoid macular edema

Pseudopemphigoid

Choroidal detachment following filtration surgery

Epiphora

Photophobia

Blurred vision

Conjunctival injection

Corneal fluorescein staining

Cataract

Retinal vascular disorder

Ptosis

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Warnings

Contraindications

Asthma, uncompensated CHF, any beta-blocker side effects, COPD, sinus bradycardia, 2nd deg or 3rd deg AV block, cardiogenic shock, hypersensitivity

Cautions

Pts receiving topical timolol and a systemic ß-adrenergic blocking agent concomitantly should be observed carefully for potential additive effects on IOP and/or systemic effects of ß-adrenergic blockade

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: secreted in breast milk; Mfr advises against breast feeding (AAP Committee states compatible with breast feeding)

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Absorption: minimal systemic

Onset: 30 min

Duration: <24 hr; max effect: 1-2 hr

Metabolism: liver

Excretion: urine

Mechanism of Action

Noncardioselective beta-blocker

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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