tolazamide (Rx)

Brand and Other Names:Tolinase
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 250mg
  • 500mg
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Type 2 Diabetes

100-250 mg PO qDay or q12hr

Increase dose by 100-250 mg/day at weekly intervals to response; not to exceed 1 g/day

Fasting blood sugar <200 mg/dL

  • 100 mg/day PO

Fasting blood sugar >200 mg/dL

  • 250 mg/day PO

Malnurished, underweight, not eating properly, or elderly

  • 100 mg/day PO

Safety and efficacy not established

Type 2 diabetes

100-250 mg PO qDay or q12hr

Increase dose by 100-250 mg/day at weekly intervals to response; not to exceed 1 g/day

Fasting blood sugar <200 mg/dL

- 100 mg/day PO

Fasting blood sugar >200 mg/dL

- 250 mg/day PO

Malnurished, underweight, not eating properly, or elderly

- 100 mg/day PO

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Interactions

Interaction Checker

and tolazamide

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hypoglycemia

            Dermatologic reactions

            Heartburn

            Dizziness

            Vertigo

            Anorexia

            Constipation

            Nausea/vomiting

            Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure

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            Warnings

            Contraindications

            Hypersensitivity, sulfa allergy

            Type I diabetes, diabetic ketoacidosis

            Cautions

            Patients with hypoglycemia, stress due to infection, fever, trauma, or surgery

            May cause loss of glycemic control due to secondary failure

            First generation sulfonylurea

            Intermediate acting agent

            Tolazamide demonstrates weak diuretic effect

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if crosses into breast milk, avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Initial effect is to increase beta-cell insulin secretion

            May also decrease rate of hepatic glucose production, increases insulin receptor sensitivity, and increases number of insulin receptors

            Pharmacokinetics

            Half-Life: 7 hr

            Duration: 14-24 hr

            Onset: 20 minutes

            Protein binding: 94%

            Peak hypoglycemic effect: 4-6 hr

            Metabolism: Hepatic to less active metabolites

            Metabolites: Inactive metabolites

            Excretion: Urine (85%); feces (7%)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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