Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

scopolamine (Rx)Brand and Other Names:Transderm Scop, Scopace, more...Maldemar

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

transdermal patch

  • 1mg/72hr
more...

Nausea & Vomiting

Treatment

0.3-0.65 mg IV/IM/SC; repeat q6-8hr if necessary

Motion Sickness

Prophylaxis

Apply 1 patch behind ear at least 4-12 hours (preferably 12 hr) before anticipated exposure to motion, then every 3 days PRN

Nausea & Vomiting Associated With Anesthesia

Prophylaxis

Transdermal patch

  • Apply 1 patch behind ear on night before scheduled surgery, then leave on for 24 hours after surgery
  • Cesarian section: Apply 1 patch behind ear 1 hour before surgery (to minimize newborn exposure, apply no sooner); remove 24 hours after surgery

Chemotherapy Induced Nausea and Vomiting (Off-label)

Apply 1 patch q72hr

Safety & efficacy not established

Next

Interactions

Interaction Checker

scopolamine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            >10%

            Dry mouth (29-67%)

            Drowsiness (17%)

            Dizziness (12%)

            Blurred vision

            Frequency Not Defined

            Disorientation

            Confusion

            Pruritus and edema at application site

            Anticholinergic effects

            Dilation of pupil if drug contacts eye

            Withdrawal symptoms (eg, dizziness, nausea and vomiting) if used for >3 days

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity to scopolamine, belladonna alkaloids, or any component in formulation

            Closed-angle glaucoma

            Cautions

            Use caution in patients with open-angle glaucoma, benign prostatic hyperplasia, history of seizures or psychosis, ulcerative colitis, hypertension, hyperthyroidism, Down syndrome, toxin-mediated diarrhea, coronary artery disease, tachyarrhythmia, brain damage or spastic paralysis in children, cardiac conduction disorder, CHF

            Children and elderly persons are particularly susceptible to side effects of belladonna alkaloids

            Anaphylaxis, including episodes of shock reported, following parenteral administration; monitor for signs and symptoms of hypersensitivity reactions

            Lower doses may increase vagal tone and cause paradoxical bradycardia

            May cause CNS depression; caution when operating heavy machinery or tasks which require mental alertness

            Patients may experience idiosyncratic toxic psychosis, agitation, delusions, confusion, hallucinations, paranoid behavior and rambling speech

            Discontinue if patient experiences unusual visual disturbances or pain within the eye

            In patients with Parkinson disease, or abrupt discontinuation of large doses may result in adverse effects, including headache, nausea, vomiting, and dizziness; withdrawal symptoms may also appear more than 24 hr after removing transdermal patch

            Drug interferes with gastric secretion test

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Drug distributed into breast milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Anticholinergic belladonna alkaloid

            Generally exhibits pharmacologic actions associated with other antimuscarinics

            May prevent motion-induced nausea and vomiting by blocking transmission of cholinergic impulse from vestibular nuclei to higher centers in CNS and from reticular formation to vomiting center

            Absorption

            Onset: IM, 0.5-1 hr; IV, 10 min

            Duration: IM, 4-6 hr; IV, 2 hr

            Peak plasma time: 24 hr (transdermal)

            Metabolism

            Metabolized by liver (via conjugation)

            Elimination

            Half-life: 9.5 hr

            Excretion: Primarily urine (90% as metabolites)

            Previous
            Next

            Administration

            IV Incompatibilities

            Alkalies, methohexital

            IV Compatibilities

            Additive: Floxacillin, furosemide, meperidine, succinylcholine

            Syringe: Atropine, butorphanol, chlorpromazine, cimetidine, diamorphine, dimenhydrinate, diphenhydramine, droperidol, fentanyl, glycopyrrolate, hydromorphone, hydroxyzine, meperidine, metoclopramide, midazolam, morphine hydrochloride, morphine sulfate, nalbuphine, papaveretum, pentazocine, pentobarbital, perphenazine, prochlorperazine, promazine, promethazine, ranitidine, sufentanil, thiopental

            Y-site: Fentanyl, heparin, hydrocortisone, hydromorphone, methadone, morphine, potassium chloride, propofol, sufentanil, vitamins B and C

            IV Preparation

            Dilute with sterile water for injection

            IV/IM Administration

            Prevention of nausea and vomiting associated with anesthesia: Inject IV/IM/SC 30-60 minutes before anticipated induction of anesthesia

            Prevention of motion sickness: Inject IM 1 hour before anticipated exposure to motion

            Storage

            Store at room temperature; protect from light

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.