Dosing & Uses
Dosage Forms & Strengths
tablet: Schedule IV
30 mg/day PO in divided doses; adjust dose gradually within range of 15-60 mg/day
When administered as single daily HS dose, initial dosage is 15 mg; after initial dose, response of patient may require subsequent dosage adjustment
7.5 mg PO q8hr; increase by < 7.5 mg/week; 90 mg/day maximum
Acute Alcohol Withdrawal
Day 1: Initial 30 mg PO once, THEN 30-60 mg in divided doses, no more than 90 mg
Day 2: 45-90 mg PO in divided doses
Day 3: 22.5-45 mg PO in divided doses
Day 4: 15-30 mg PO in divided doses
Day 5 onwards: 7.5-15 mg PO in divided doses
Discontinue when stable
Dosage Forms & Strengths
tablet: Schedule IV
<9 years: Not recommended
9-12 years: 7.5 mg PO BID initially; increase by <7.5 mg qWeek to 60 mg/day maximum
>12 years: As in adults
Not drug of choice in elderly because of long-acting metabolite; long-acting benzodiazepines associated with falls in elderly
7.5 mg PO qDay or q12hr
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Anterograde amnesia may occur
May cause CNS depression
May experience aggressive behavior
Caution in patients with a history of drug abuse; tolerance, psychological, and physical dependence may occur with prolonged use
Caution in patients with gag reflex
Caution in patients with respiratory disease
Caution in hepatic impairment
Pregnancy & Lactation
Pregnancy Category: Not available. An increased risk of congenital malformations associated with the use of minor tranquilizers during the first trimester of pregnancy has been suggested in several studies. Pregnant patients taking clorazepate should enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling 1-888-233-2334. More information can be found at http://www.aedpregnancyregistry.org
Lactation: enters breast milk; do not nurse
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to chloride ions
Half-Life: 50-70 hr
Time to peak: ~ 1 hr
Protein Bound: 97-98%
Metabolism: Hydroxylation, glucuronic acid conjugation
Metabolites: Desmethyldiazepam (nordiazepam), oxazepam
Onset of action: 1-2 hr
Duration: Variable 8-24 hr
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.