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pentoxifylline (Rx)Brand and Other Names:Trental, Pentoxil, more...Pentoxifylline SR

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet, extended release

  • 400mg
more...

Intermittent Claudication

400 mg PO q8hr

Recommended duration of treatment: ≥8 weeks

Dosage Modifications

Digestive or CNS side effects: Decrease dose to 400 mg BID; discontinue if adverse effects persist

Renal impairment (CrCl <30 mL/min): Decrease dose to 400 mg/day

Hepatic impairment: No information

Administration

Take with meals

Safety and efficacy not established

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Interactions

Interaction Checker

pentoxifylline and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Nausea

            Vomiting

            <1%

            Angina

            Anaphylaxis

            Anorexia

            Aplastic anemia

            Pancytopenia

            Conjunctivitis

            Angioedema

            Aseptic meningitis

            Chest pain

            Leukemia

            Leukopenia

            Cholecystitis

            Hepatitis

            Seizure

            Scotoma

            Thrombocytopenia

            Increased live enzyme

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            Warnings

            Contraindications

            Hypersensitivity to pentoxifylline or xanthine derivatives

            Recent retinal or cerebral hemorrhage

            Cautions

            Use caution with risk factors for hemorrhage

            Discontinue at first sign of anaphylaxis

            Use with caution in renal impairment; exposure to pentoxifylline and/or active metabolites may increase; significance unknown

            Use with caution in the elderly due to potential for renal impairment

            Use with caution in hepatic impairment; exposure to pentoxifylline and/or active metabolites may increase; significance unknown

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Drug excreted in breast milk; discontinue therapy, or do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Improves blood flow by decreasing blood viscosity and increasing red blood cell (RBC) flexibility

            May increase tissues oxygenation through enhanced blood flow

            Absorption

            Bioavailability: 10-30%

            Distribution

            RBC binding: Parent drug, 45%; 5-hydroxyhexyl metabolite, 40%

            Metabolism

            Extensively metabolized in liver (first pass); also metabolized in erythrocytes

            Metabolites: 5-hydroxyhexyl, 3-carboxypropyl

            Elimination

            Half-life: 24-48 min (Parent drug); 60-96 min (metabolites)

            Excretion: Urine (50-80%, principally as metabolites), feces (<4%)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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