fluocinolone/tretinoin/hydroquinone (Rx)Brand and Other Names:Tri-Luma

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

fluocinolone/tretinoin/hydroquinone

cream

  • (0.01%/4%/0.05%)/30g
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Melasma

Indicated for short-term treatment of moderate to severe melasma

Apply to face qHS, at least 30 min before bedtime

Wash face gently before application; rinse & pat dry

Apply thin film of Tri-Luma to hyperpigmented area & 1/2 inch surrounding skin

Do not use occlusive dressing

Safety & efficacy not established

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Interactions

Interaction Checker

fluocinolone/tretinoin/hydroquinone and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Erythema (41-45%)

            Desquamation (36-40%)

            Burning (16-20%)

            Dryness (11-15%)

            Pruritis (11-15%)

            1-10%

            Acne (5%)

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Not indicated for maintenance treatment of melasma

            Avoid sun exposure

            Safety & efficacy of Tri-Luma in pts of skin types V and VI not studied. Excessive bleaching in pts with darker skin cannot be excluded.

            Safety & efficacy in Tx of hyperpigmentation conditions other than melasma of face not studied

            Contains sodium matabisulfite which may cause allergic-type reactions in susceptible pts.

            Hydroquinone may produce exogenous ochronosis (darkening of skin)- promptly discontinue if occurs

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known whether excreted in breast milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Absorbed: minimal

            Mechanism of Action

            Hydroquinone: Inhibits melanocyte metabolic processes that produce melanin; incr excretion of melanin from melanocytes

            Fluocinolone: Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes

            Tretinoin: Follicular epithelium irritant

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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