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vandetanib (Rx)Brand and Other Names:Caprelsa


Dosing & Uses


Dosage Forms & Strengths


  • 100mg
  • 300mg

Medullary Thyroid Cancer

Indicated for treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease

300 mg PO qDay with or without food

Continued until patients are no longer benefiting from treatment or an unacceptable toxicity occurs

Dose Reduction

  • Dose reduction may be necessary with emergence of severe toxicities or QTc interval prolongation
  • In event of QTc interval >500 ms, interrupt dosing until <450 ms, then resume at a reduced dose
  • In the presence of CTCAE (Common Terminology Criteria for Adverse Events) grade 3 or greater, interrupt dosing until toxicity resolves or improves to grade 1, then resume at reduced dose
  • 300 mg daily dose may be reduced to 200 mg/day and then 100 mg for CTCAE grade 3 or greater

Renal and Hepatic Impairment

CrCl 50 mL/min or greater: Dose adjustment not necessary

Moderate (CrCl 30 to <50 mL/min) to severe (CrCl <30 mL/min) renal impairment: Reduce starting dose to 200 mg PO qDay

Hepatic Impairment

Mild liver impairment: Dose adjustment not described in manufacturer's label

Moderate-to-severe liver impairment (Child-Pugh B/C): Not recommended because of limited data


If a patient misses a dose, the missed dose should not be taken if it is <12 hours before the next dose

Vandetanib tablets should not be crushed

Only available via restricted access prescribing and dispensing program, to enroll in the Vandetanib REMS Program, call 1-800-817-2722 or visit

Dispersing tablets in water to aid swallowing

  • If patient unable to swallow tablet whole, disperse tablet in 2 ounces of noncarbonated water and stir for approximately 10 minutes until the tablet is dispersed (will not completely dissolve); no other liquids besides water should be used
  • The dispersion should be swallowed immediately
  • To ensure the full dose is received, any residues in the glass should be mixed again with an additional 4 ounces of noncarbonated water and swallowed
  • The dispersion can also be administered via NG or GT
  • Avoid direct contact of crushed tablets with the skin or mucous membranes; if contact occurs, wash thoroughly

Safety and efficacy not established



Interaction Checker

vandetanib and

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      Serious - Use Alternative

        Significant - Monitor Closely


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            Adverse Effects


            Diarrhea (57%)

            Rash (53%)

            Dermatitis acneiform/acne (35%)

            Nausea (33%)

            Hypertension/Hypertensive Crisis/Accelerated Hypertension (33%)

            Headache (26%)

            Fatigue (24%)

            Upper respiratory tract infection (23%)

            Decreased appetite (21%)

            Abdominal pain (21%)

            Dry skin (15%)

            Vomiting (15%)

            QT prolongation (14%)

            Photosensitivity reaction (13%)

            Corneal abnormalities (13%)

            Dyspepsia (11%)

            Hypocalcemia (11%)

            Pruritus (11%)


            Proteinuria (10%)

            Depression (10%)

            Dry mouth (9%)

            Nail abnormalities (9%)

            Blurred vision (9%)

            Alopecia (8%)

            Dysgeusia (8%)

            Hypothyroidism (6%)

            Muscle spasms (6%)


            Intestinal perforation (0.4%)



            Black Box Warnings

            Can prolong the QT interval

            Torsades de pointes and sudden death have been reported

            Should not be used in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome

            Hypocalcemia, hypokalemia, and/or hypomagnesemia must be corrected prior to administration and should be periodically monitored

            Drugs known to prolong QT interval should be avoided

            If a drug known to prolong the QT interval must be administered, more frequent ECG monitoring is recommended

            Given the half-life of 19 days, ECGs should be obtained to monitor the QT at baseline, at 2-4 weeks and 8-12 weeks after starting treatment with vandetanib and every 3 months thereafter

            Following any dose reduction for QT prolongation, or any dose interruptions greater than 2 weeks, QT assessment should be conducted as described above

            Because of the 19-day half-life, adverse reactions including a prolonged QT interval may not resolve quickly

            Monitor appropriately

            Only prescribers and pharmacies certified with the restricted distribution program are able to prescribe and dispense vandetanib



            Congenital long QT syndrome


            Use in patients with indolent, asymptomatic, or slowly progressing disease should be carefully considered because of the treatment related risks

            Prolonged QT Interval, Torsades de pointes, and sudden death have been reported

            Obtain ECG, serum potassium, calcium, magnesium, and TSH at baseline, then 2-4 and 8-12 weeks after treatment initiation, then q3months for at least a year thereafter; reduce dose as appropriate

            Potent CYP3A4 inducers reduce exposure to vandetanib by up to 40%; however, no clinically significant effect on exposure to vandetanib was observed in the presence of the potent CYP3A4 inhibitors

            Stevens-Johnson syndrome resulting in death has been observed; severe skin reactions may prompt permanent discontinuation of vandetanib

            Interstitial lung disease (ILD), resulting in death has been reported; interrupt vandetanib and investigate unexplained dyspnea, cough, and fever; appropriate measures should be taken for ILD

            Ischemic cerebrovascular events, hemorrhage, heart failure, diarrhea, hypothyroidism, hypertension, and reversible posterior leukoencephalopathy syndrome, have been observed

            Can cause fetal harm when administered to pregnant women; avoid pregnancy while receiving vandetanib and for 4 months following treatment

            Serious hemorrhagic events, some fatal, have been observed; do not administer with recent history of hemoptysis and discontinue if severe hemorrhage occurs

            Heart failure observed, including some fatal cases; may be necessary to discontinue vandetanib; heart failure may not be reversible

            Diarrhea is common and routine antidiarrheal agents are recommended to avoid electrolyte disturbances that may exacerbate risk of QT prolongation

            Hypothyroidism: 90% of patients enrolled in clinical trials had prior thyroidectomy, 49% of patients randomized to vandetanib required increased thyroid doses compared with 17% of patients in the placebo arm

            Hypertension, including hypertensive crisis may occur

            The most common laboratory abnormalities (>20%) were decreased calcium, increased ALT, and decreased glucose

            Hypersensitivity including anaphylaxis has been reported

            Reversible posterior leukoencephalopathy syndrome (RPLS)

            • Syndrome of subcortical vasogenic edema diagnosed by an MRI of the brain, has been observed
            • This syndrome should be considered in any patient presenting with seizures, headache, visual disturbances, confusion or altered mental function
            • In clinical studies, 3 or 4 patients who developed RPLS while taking vandetanib, including one pediatric patient, also had hypertension
            • Consider discontinuation of vandetanib treatment in patients with RPLS

            Pregnancy & Lactation

            Pregnancy Category: D

            If vandetanib is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus

            Women of childbearing potential should be advised to avoid becoming pregnant during treatment with vandetanib

            Women should be advised that they must use effective contraception to prevent pregnancy during treatment and for at least 4 months following the last dose of vandetanib

            Lactation: Unknown whether distributed in breast milk; do not breastfeed during or for at least 4 months following last dose of vandetanib

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.



            Mechanism of Action

            Tyrosine kinase inhibitor (TKI) with selective activity against RET, VEGFR-2, and EGFR; TKI inhibition blocks angiogenesis and cellular proliferation


            Peak Plasma Time: 6 hr (range 4-10 hr)

            Steady State: ~3 months; accumulates ~8-fold with multiple dosing


            Protein Bound: 90%

            Vd: 7450 L


            Metabolized by CYP3A4


            Half-Life: 19 days

            Clearance: 13.2 L/hr

            Excretion: feces (44%), urine (25%); 21 day collection period after single dose


            There is no evidence of a relationship between RET mutations and efficacy of vandetanib

            20% of medullary thyroid carcinomas are associated with 1 of 3 inherited endocrine syndromes caused by germline mutations of the RET gene RET encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of extracellular signaling molecules

            A gain of function mutations are associated with cancer (eg. medullary thyroid carcinoma, multiple endocrine neoplasias)

            Vandetanib has activity against RET as well as vascular endothelial growth factor (VEGF)





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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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