eflornithine cream (Rx)

Brand and Other Names:Vaniqa
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream

  • 13.9%
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Reduction of Facial Hair in Women

Apply to affected area twice daily at least 8 hours apart

Dosage Forms & Strengths

cream

  • 13.9%
more...

Reduction of Facial Hair in Women

<12 years: Safety & efficacy not established

>12 years: Apply to affected area twice daily at least 8 hours apart

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Adverse Effects

Frequency Not Defined

Acne

Pseudofolliculitis barbae

Burning

Stinging

Dry, and/or tingling skin

Erythema

Anorexia

Neutropenia

Injection site reaction

Myalgia/arthralgia

Rash

Pruritus

Alopecia

Fever

Arrhythmia

Chest pain

Headache

Dizziness

Dyspepsia

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Warnings

Contraindications

Hypersensitivity

Cautions

Discontinue if sensitivity occurs

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Not known whether distributed into breast milk; use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

May inhibit ornithine decarboxylase (ODC), an enzyme that catalyzes biosynthesis of intracellular polyamines required for cell division & differentiation, which in turn can affect hair growth

Pharmacokinetics

Absorption: < 1%

Half-life: 8 hr

Excretion: Urine (primarily)

Onset of action: 4-8 weeks (decreased hair growth)

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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