benzoyl peroxide/hydrocortisone (Rx)

Brand and Other Names:Vanoxide-HC
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

benzoyl peroxide/hydrocortisone

topical lotion

  • 5%/0.5%
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Acne Vulgaris

Apply a thin film to the affected area qDay-TID; massage gently into skin

Dosage Forms & Strengths

benzoyl peroxide/hydrocortisone

topical lotion

  • 5%/0.5%
more...

Acne Vulgaris

<12 years: Safety and effectiveness not established

≥12 years: Apply a thin film to the affected area qDay-TID; massage gently into skin

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Adverse Effects

Frequency Not Defined

Benzoyl Peroxide

  • Irriation
  • Contact dermatitis
  • Dryness
  • Erythema
  • Stinging
  • Peeling

Hydrocortisone

  • Acneform eruptions
  • Allergic contact dermatitis
  • Skin atrophy
  • Burning
  • Dryness
  • Folliculitis
  • Hypertrichosis
  • Hypopigmentation
  • Itching
  • Irritation
  • Miliaria
  • Perioral dermatitis
  • Secondary infection
  • Striae
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Warnings

Contraindications

Hypersensitivity to benzoyl peroxide, hydrocortisone or any components

Patients with viral or fungal diseases of the skin

Cautions

For external use only; avoid contact with the eyes, lips, and mouth

May cause suppression of hypothalamic-pituitary-adrenal axis, leading to adrenal crisis in young patients or patients receiving large topical doses for prolonged periods

Discontinue use if irritation, redness, itching, swelling, or undue dryness occurs

Risk of secondary skin infections may increase

Incidence of Kaposi's sarcoma associated with prolonged corticosteroid treatments

Coadministration with other topical acne medications may increase skin irritation and dryness; avoid excessive sun exposure and use sunscreen

Avoid contact with hair and dyed fabrics (eg, pillow cases, towels), which may be bleached by this product

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Benzoyl Peroxide

  • Elicits action by releasing active oxygen
  • Effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones
  • Elicits keratolytic and desquamative effect, which may contribute to its efficacy

Hydrocortisone

  • Decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes
  • Inhibits macrophage accumulation in inflamed areas
  • Reduces leukocyte adhesion to capillary endothelium
  • Reduces capillary wall permeability and edema formation
  • Decreases complement components and antagonizes histamine activity and release of kinin from substrates
  • Reduces fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Pharmacokinetics

Benzoyl peroxide

  • Absorbed by the skin where it is converted to benzoic acid

Hydrocortisone

  • Percutaneous absorption of topical steroids increased by occlusive dressing
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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
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  • Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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