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varicella virus vaccine live (Rx)Brand and Other Names:Varivax

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

vaccine

  • 1350 plaque forming units/0.5mL
more...

Varicella Immunization

Indicated for all adults without evidence of immunity to varicella

2 dose series: 0.5 mL SC, repeat at least 4 weeks later

Vaccination Schedules

Up-to-date vaccination schedules available at http://www.cdc.gov/vaccines/schedules/

Dosage Forms & Strengths

vaccine

  • 1350 plaque forming units/0.5mL
more...

Varicella Immunization

Indicated for routine immunization (ACIP guidelines)

Minimum age: 12 months

Routine vaccination

  • 2 dose series: 0.5 mL SC
  • 1st dose: 12-15 months
  • 2nd dose: 4-6 years; may be administered before age 4 yr, provided at least 3 months have elapsed since the first dose
  • Note: If the 2nd dose was administered at least 4 weeks after the first dose, it can be accepted as valid

Catch-up vaccination aged 7-18 yr

  • 7-12 years: 0.5 mL SC x2 doses at least 3 months apart; if the second dose was administered at least 4 weeks after the first dose, it can be accepted as valid
  • ≥13years: 0.5 mL SC x2 doses at least 4 weeks apart
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Interactions

Interaction Checker

varicella virus vaccine live and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            >10%

            Injection site swelling/rash/pruritus/erythema (20%)

            Fever >102°F [39°C] (15%)

            Postmarketing Reports

            Body as a whole: Anaphylaxis (including anaphylactic shock) and related phenomena such as angioneurotic edema, facial edema, and peripheral edema

            Eye disorders: Necrotizing retinitis (in immunocompromised individuals)

            Hemic and lymphatic system: Aplastic anemia; thrombocytopenia (including ITP)

            Infections and infestations: Varicella (vaccine strain)

            Nervous/psychiatric: Encephalitis; cerebrovascular accident; transverse myelitis; Guillain-Barré syndrome; Bell palsy; ataxia; nonfebrile seizures; aseptic meningitis; dizziness; paresthesia

            Respiratory: Pharyngitis; pneumonia/pneumonitis

            Skin: Stevens-Johnson syndrome; erythema multiforme; Henoch-Schönlein purpura; secondary bacterial infections of skin and soft tissue, including impetigo and cellulitis; herpes zoster

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            Warnings

            Contraindications

            Hypersensitivity to gelatin, neomycin

            Pregnancy

            HIV: CD4+ count <200 cells/mcL

            Immunosuppressed or immunodeficient patients with lymphomas, leukemia, or malignant neoplasms affecting bone marrow or lymphatic system

            Patients receiving immunosuppressive therapy including immunosuppressive doses of corticosteroids

            Primary and acquired immunodeficiency states

            Current febrile illness

            Active TB

            Cautions

            Avoid contact with high risk individuals up to 5 wk after vaccination

            Do not give concurrently w/ any form of immune globulin

            Thermolabile: store at temperature -20°C or colder

            Syncope accompanied by transient visual disturbances, weakness, or tonic-clonic movements reported with injectable vaccines

            Postpone administration in patients with moderate or severe illness with or without fever; may administer to patients with mild illness with or without fever

            Avoid pregnancy for 3 months following therapy

            Avoid taking salicylates for 6 weeks after vaccination (may increase risk of Reye's syndrome

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: Not known if excreted in breast milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Live, attenuated varicella virus stimulates active immunity to disease caused by varicella-zoster virus

            Conveys active immunity via stimulation of production of endogenously produced antibodies

            Pharmacokinetics

            Onset: 4-6 weeks (seroconversion)

            Duration: Antibody titers detected at 10 years following vaccination

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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