phenylephrine (Rx)

Brand and Other Names:Vazculep
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 10mg/mL
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Mild to Moderate Hypotension

Initial: 2-5 mg IM or SC; not to exceed 5 mg

Maintenance: 1-10 mg

Severe Hypotension/Shock

100-180 mcg increments IV bolus, THEN

40-60 mcg/min continuous IV infusion

Dosage Forms & Strengths

injectable solution

  • 10mg/mL
more...

Hypotension

5-20 mcg/kg IV bolus q10-15min PRN, OR  

0.1-0.5 mcg/kg/min IV continuous infusion

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Interactions

Interaction Checker

and phenylephrine

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Extravasation

            Hypertension

            Reflex bradycardia

            Anxiety

            Headache

            Burning

            Rebound congestion

            Sneezing

            Pulmonary edema

            Metabolic acidosis

            Decreased renal perfusion

            Reduced urine output

            Nausea

            Gastric irritation

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            Warnings

            Black Box Warnings

            Physicians should completely familiarize themselves with complete contents of package insert prior to prescribing phenylephrine hydrochloride injection

            Contraindications

            Hypersensitivity to phenylephrine or sulfites

            Severe hypertension

            Ventricular tachycardia

            Closed-angle glaucoma

            Cautions

            Cerebrovascular insufficiency

            Cardiovascular disease

            Hypertension

            Diabetes mellitus

            Thyroid disease

            Prostatic hypertrophy

            Geriatric patients

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Safe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Strong alpha effects resulting in increased peripheral vascular resistance and blood pressure; decreases cardiac output and renal perfusion

            Absorption

            Bioavailability: <38%

            Onset: 10-15 min

            Duration: 15 min

            Peak plasma time: 0.75-2 hr

            Distribution

            Vdss: 184-543 L

            Metabolism

            Extensively metabolized in intestinal wall; moderately metabolized in liver

            Metabolites: M-hydroxymandelic acid (inactive)

            Elimination

            Half-life: 2-3 hr (terminal phase)

            Excretion: Urine (80-90%)

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            Administration

            IV Compatibilities

            Additive: Chloramphenicol, dobutamine, lidocaine, KCl, Na bicarb

            Y-site: Amiodarone, amrinone, famotidine, haloperidol

            IV Preparation

            10 mg in 250 mL D5W (40 mcg/mL); at 2-5 mL/min (80-200 mcg/min)

            100-500 mg in 250 mL have been used

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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