Brand and Other Names:Vazculep
- Classes: Alpha1 Agonists
Dosing & Uses
Dosage Forms & Strengths
Mild to Moderate Hypotension
Initial: 2-5 mg IM or SC; not to exceed 5 mg
Maintenance: 1-10 mg
100-180 mcg increments IV bolus, THEN
40-60 mcg/min continuous IV infusion
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Decreased renal perfusion
Reduced urine output
Black Box Warnings
Physicians should completely familiarize themselves with complete contents of package insert prior to prescribing phenylephrine hydrochloride injection
Hypersensitivity to phenylephrine or sulfites
Pregnancy & Lactation
Pregnancy category: C
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Strong alpha effects resulting in increased peripheral vascular resistance and blood pressure; decreases cardiac output and renal perfusion
Onset: 10-15 min
Duration: 15 min
Peak plasma time: 0.75-2 hr
Vdss: 184-543 L
Extensively metabolized in intestinal wall; moderately metabolized in liver
Metabolites: M-hydroxymandelic acid (inactive)
Half-life: 2-3 hr (terminal phase)
Excretion: Urine (80-90%)
Additive: Chloramphenicol, dobutamine, lidocaine, KCl, Na bicarb
Y-site: Amiodarone, amrinone, famotidine, haloperidol
10 mg in 250 mL D5W (40 mcg/mL); at 2-5 mL/min (80-200 mcg/min)
100-500 mg in 250 mL have been used
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