Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

iron sucrose (Rx)Brand and Other Names:Venofer

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 20mg (Fe)/mL
more...

Iron-deficiency Anemia in Chronic Kidney Disease

Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week

Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period)

Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week)

Dosage Forms & Strengths

injectable solution

  • 20mg (Fe)/mL
more...

Iron-deficiency Anemia in Chronic Kidney Disease

Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease

<2 years: Safety and efficacy not established

Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose

Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose

Next

Interactions

Interaction Checker

iron sucrose and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            >10%

            Hypotension (36%)

            Muscle cramps (23%)

            Headache

            Nausea

            1-10%

            Dizziness

            Fatigue

            Arthralgia

            Back pain

            Hypertension

            Fluid overload

            Peripheral edema

            Cough

            Vomiting

            Diarrhea

            Constipation

            Pruritus

            Frequency Not Defined

            Potentially fatal anaphylaxis (rare)

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity

            Anemia not caused by iron deficiency

            Iron overload

            Cautions

            Risk of hypotension

            Withhold therapy in tissue iron overload

            Hypersensitivity

            • Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal
            • Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse
            • If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately
            • Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion
            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: Not known if excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin

            Pharmacokinetics

            Half-life elimination: 6 hr

            Vd: 7.9-10 L

            Clearance: 1.2 L/hr

            Excretion: Urine (5%)

            Previous
            Next

            Administration

            IV Incompatibilities

            Do not mix with other medications or add to parenteral nutrition solutions for IV infusion

            IV Compatibilities

            Solution: NS

            IV Administration

            HD-dependent CKD

            • May be administered via dialysis line as the undiluted solution or by diluting 100 mg (5 mL) in 100 mL NS
            • Administer either by slow IV injection over 2-5 min or IV infusion over at least 15 min

            Non-dialysis-dependent CKD

            • Administer undiluted by slow IV inj over 2-5 min

            PD-dependent CKD

            • Dilute dose in a maximum of 250 mL NS
            • 300 mg doses: infuse IV over 1.5 hr
            • 400 mg dose: infuse IV over 2.5 hr

            Pediatric

            • Undiluted: Administer by slow IV injection over 5 minutes
            • Diluted in 25 mL of 0.9% NaCl: Administer IV over 5-60 minutes

            Storage

            Store vials at room temp; do not freeze

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.