doxylamine/dextromethorphan (OTC)

Brand and Other Names:Vicks NyQuil Cough, Safetussin PM
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

doxylamine/dextromethorphan

oral liquid

  • (6.25mg/15mg)/15mL
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Cough, Rhinorrhea & Sneezing

30 mL PO q6hr; not to exceed 4 doses/day

Dosage Forms & Strengths

doxylamine/dextromethorphan

oral liquid

  • (6.25mg/15mg)/15mL
more...

Cough, Rhinorrhea & Sneezing

<4 years: Do not use

4-12 years: Ask a pediatrician

>12 years: 30 mL PO q6hr; not to exceed 4 doses/day

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Interactions

Interaction Checker

and doxylamine/dextromethorphan

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            Adverse Effects

            Common Adverse Effects

            Agranulocytosis

            Potential for abuse

            Leukopenia

            Serotonin syndrome

            Dizziness

            Drowsiness

            Thrombocytopenia

            Toxic psychosis

            GI disturbances

            Dry mouth, throat, and nose

            Thickening of mucus in nose or throat

            Constipation

            Blurred vision

            Headache

            Urinary retention

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            Warnings

            Contraindications

            Hypersensitivity

            Asthma attacks

            Use of MAO inhibitors within 14 days

            < 2 years of age

            Narrow-angle glaucoma

            Breastfeeding

            Symptomatic prostate hypertrophy

            Bladder-neck obstruction

            Stenosing peptic ulcer

            Cautions

            Caution in patients < 6 years of age

            Doxylamine: Caution in used concomitantly with another CNS deppressatn; may exacerbate angle closure glaucoma, hyperthyroidism, peptic ulcer, or urinary tract obstruction; xerostomia may occur; caution in COPD, cardiovascular disease, asthma, increased intraocular pressure, elderly patients or GI obstruction

            Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: excreted in breast milk, use caution

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Doxylamine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity & penetrates CNS, which causes pronounced tendency to induce sedation

            Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla

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