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thiamine (Rx, OTC)Brand and Other Names:vitamin B1

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 50mg
  • 100mg
  • 250mg

capsule

  • 50mg

injectable solution

  • 100mg/mL
more...

RDA

Males: 1.2 mg/day

Females: 1.1 mg/day

Pregnancy/Lactation: 1.4 mg/day

Beriberi

IM: 5-30 mg three times daily (if critically ill); then 5-30 mg three times daily for 1 month

Duration dependent on persistence of symptoms

Wernicke Encephalopathy

100 mg IV; then 50-100 mg/day IM or IV until consuming regular balanced diet

Thiamin Deficiency

1 tablet or capsule/day

Need for thiamin increases when carbohydrate content of diet is high

Dosage Forms & Strengths

tablet

  • 50mg
  • 100mg
  • 250mg

capsule

  • 50mg

injectable solution

  • 100mg/mL
more...

RDA

0-6 months: 0.2 mg/day

6-12 months: 0.3 mg/day

1-3 years old: 0.5 mg/day

3-8 years old: 0.6 mg/day

8-13 years old: 0.9 mg/day

13-18 years old: 1.2 mg/day (male), 1 mg/day (female)

Deficiency

10-50 mg/day PO in divided doses

Beriberi

10-25 mg IV/IM qDay (if crtically ill) or 10-50 mg/dose PO qDay for at least 2 weeks, THEN

5-10 mg/day PO for 1 month

Duration dependent on persistence of symptoms

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Interactions

Interaction Checker

thiamine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Warmth

            Anaphylaxis

            Cyanosis

            Diaphoresis

            Restlessness

            Angioneurotic edema

            Pruritus

            Urticaria

            Pulmonary edema

            Weakness

            Tightness of the throat

            Nausea

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            In pregnancy (doses >RDA)

            Acute thiamine deficiency reported with dextrose administration; use caution when thiamine status uncertain

            Hypersensitivity reactions reported following repeated parenteral doses

            Parenteral products may contain aluminum; use caution in patients with impaired renal function

            Evaluate for additional vitamin deficiencies if patient diagnosed with thiamin deficiency; single vitamin deficiencies are rare

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            Pregnancy & Lactation

            Pregnancy Category: A (injectable); C (if >RDA)

            Lactation: Safe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Nutrition

            Sources: brewer's yeast, pork, ham, liver, whole grains, peas, beans, milk

            Function: cofactor in glucose metabolism

            Deficiency: (common in alcoholics, Asians, dialysis patients, those on high carbohydrate diet) Beriberi; causes nerve damage, dementia, heart failure; sometimes irreversible

            Reduced/Destroyed by

            Heat-labile thiaminases contained in milled rice, raw shellfish & freshwater fishes

            Heat-stable anti-thiamine factor in coffee/tea

            Sulfite-containing foods

            Alcohol

            High temp

            Toxicity Symptoms

            Toxicity: rare; intake of >400 mg/d; lethargy, balance problems, intestinal problems

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            Pharmacology

            Mechanism of Action

            Forms thiamine pyrophosphate by combining with adenosine triphosphate; essential coenzyme in carbohydrate metabolism

            Pharmacokinetics

            Distribution: Distributes mainly to heart, brain, kidney, and liver

            Excretion: Urine

            Absorption: Adequate (PO); rapid and complete (IM)

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            Administration

            When oral administration is not feasible

            When malabsorption is suspected

            In patients with Wernicke's encephalopathy or high-output heart failure secondary to beriberi

            IV administration preferred for high-output heart failure

            Compatible with most common diluents (dextrose solutions; LR, Ringer's; dextrose-saline solutions; dextrose/LR; NS; ½NS; fat emulsion 10%; Na-lactate 1M/6

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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